1.1.1.252: tetrahydroxynaphthalene reductase

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For detailed information about tetrahydroxynaphthalene reductase, go to the full flat file.

Reaction

Synonyms

1,3,6,8-tetrahydroxynaphthalene reductase, 1,3,8-trihydroxynaphthalene reductase, 3HNR, 4HN, BdsA, EC 1.3.1.50, hydroxynaphthalene reductase, MGG_02252, NADPH-dependent naphthol reductase, naphthol reductase, reductase, naphthol, reductase, naphthol (Magnaporthe grisea clone pAV501 precursor reduced), T4HN reductase, T4HNR, tetrahydroxynaphthalene reductase (Magnaporthe grisea clone pAV501), THNR, trihydroxynaphthalene reductase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.252 tetrahydroxynaphthalene reductase

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Results	in table
33	AA Sequence
5	Application
2	CAS Registry Number
7	Cloned(Commentary)
18	Cofactor
3	Crystallization (Commentary)
5	General Information
27	IC50 Value
64	Inhibitors
20	Ki Value [mM]
11	KM Value [mM]
3	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
24	Organism
8	PDB ID
4	pH Optimum
2	pH Range
1	Protein Variants
6	Purification (Commentary)
2	Reaction
2	Reaction Type
24	Reference
3	Specific Activity [micromol/min/mg]
1	Storage Stability
82	Substrates and Products (Substrate)
4	Subunits
27	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
4	Turnover Number [1/s]

General Information

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General Information on EC 1.1.1.252 - tetrahydroxynaphthalene reductase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Pyricularia grisea

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the enzyme is a member of the short-chain dehydrogenase/reductase (SDR) family of enzymes

723949

metabolism

Pyricularia grisea

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the enzyme catalyzes a step in 1,8-dihydroxynaphthalene-melanin biosynthesis, overview

723949

physiological function

2 entries

additional information

Pyricularia grisea

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structure-activity relationship of T4HNR and dynamics of its catalytic cycle, substrate docking study, the carboxylate of Ile274 might have an impact on substrate orientation, overview. Two orientations of tetralones in the active site of T4HNR revealed by docking studies: 1. si-face orientation (representing the preferential hydrophobic interaction of the methoxy group of substrate 5-methoxy-2-tetralone) and 2. the re-face orientation

723949

physiological function

Lomentospora prolificans

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enzyme-deficient mutants produce orange-brown or green-brown spore suspensions compared with the black spore suspension of the wild-type strain

740381

physiological function

Sorangium cellulosum

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expression of genes CHS1, BdsA, and BdsB is necessary and sufficient for the production of 1,8-dihydroxynaphthalene in a heterologous host. Polyketide synthase CHS1 catalyzes the synthesis of 1,3,6,8-tetrahydroxynaphthalene (T4HN) in vitro. T4HN is converted to 1,8-dihydroxynaphthalene by successive steps of reduction and dehydration, which are catalyzed by BdsA and BdsB. BdsA catalyzes the reduction of T4HN and 1,3,8-trihydroxynaphthalene (T3HN) to scytalone and vermelone, respectively. T4HN reduction by BdsA occurs on the si-face to give (R)-scytalone with more than 99% optical purity

762638