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1.1.1.247: codeinone reductase (NADPH)

This is an abbreviated version!
For detailed information about codeinone reductase (NADPH), go to the full flat file.

Word Map on EC 1.1.1.247

Reaction

codeine
+
NADP+
=
codeinone
+
NADPH
+
H+

Synonyms

codeine oxidase, codeine: NADP oxidoreductase, codeine:NADP oxidoreductase, codeinone reductase, codeinone reductase (NADPH), CodR, COR, COR-B, COR1.1, COR1.2, COR1.3, COR1.4, PsCor1.1, reductase, codeinone (reduced nicotinamide adenine dinucleotide phosphate)

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.247 codeinone reductase (NADPH)

General Information

General Information on EC 1.1.1.247 - codeinone reductase (NADPH)

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
deduction and calculation of sequences of codeinone reductase isoforms COR1.1, COR1.2, COR1.3, COR1.4, and COR-B, overview. In 3-h assays using codeine and NADP+ as substrates, isozyme COR-B yields the most neopine, followed by COR1.4, COR1.2, COR1.1, and COR1.3. The four residues (V25, K41, F129 and W279) responsible for the differential function of COR-B, compared with COR1.1-1.4, are predominant among COR isoforms in various opium poppy chemotypes
metabolism
physiological function
codeinone reductase (COR) catalyzes the reversible NADPH-dependent reduction of codeinone to codeine as the penultimate step of morphine biosynthesis in opium poppy (Papaver somniferum). It also irreversibly reduces neopinone, which forms by spontaneous isomerization in aqueous solution from codeinone, to neopine. In a parallel pathway involving 3-O-demethylated analogs, COR converts morphinone to morphine, and neomorphinone to neomorphine
additional information