1.1.1.245: cyclohexanol dehydrogenase

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For detailed information about cyclohexanol dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.245

Reaction

Cyclohexanol
+
NAD+
=
cyclohexanone
+
NADH
+
H+

Synonyms

alcohol dehydrogenase, CHXON, cyclohexanol dehydrogenase II, dehydrogenase, cyclohexanol, SSADH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.245 cyclohexanol dehydrogenase

Application

Application on EC 1.1.1.245 - cyclohexanol dehydrogenase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
synthesis of lactones from cycloalkanes. A heterologous pathway comprising enzymes with compatible kinetics is designed in Pseudomonas taiwanensis VLB120 enabling in-vivo cascade for synthesizing lactones from cycloalkanes. The respective pathway includes cytochrome P450 monooxygenase (CHX), cyclohexanol dehydrogenase (CDH), and cyclohexanone monooxygenase (CHXON) from Acidovorax sp. CHX100. Resting cells of the recombinant host Pseudomonas taiwanensis VLB120 convert cyclohexane, cyclohexanol, and cyclohexanone to epsilon-caprolactone at 22, 80-100, and 170 U/g cell dry weight, respectively. Cyclohexane (5 mM) is completely converted with a selectivity of 65% for epsilon-caprolactone formation in 2 h without accumulation of intermediate products