1.1.1.23: histidinol dehydrogenase
This is an abbreviated version!
For detailed information about histidinol dehydrogenase, go to the full flat file.
Reaction
Synonyms
11412251, BN980_GECA03s06082g, BsHDH, GcHDH, HDH, HIS4 protein, HisD, histidinol dehydrogenase, HLDase, L-histidinol dehydrogenase
ECTree
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Engineering
Engineering on EC 1.1.1.23 - histidinol dehydrogenase
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C112A
-
conserved Cys-112 is not involved in catalysis, Cys-112 corresponds to Cys-116 in Salmonella typhimurium
C366S
H261N
-
mutation causes complete loss of Zn and activity
additional information
site-directed mutagenesis of hisD, resulting in the replacement of the five His-residues with asparagine or glutamine, causes an important decrease in kcat for His261 and His326