1.1.1.229: diethyl 2-methyl-3-oxosuccinate reductase
This is an abbreviated version!
For detailed information about diethyl 2-methyl-3-oxosuccinate reductase, go to the full flat file.
Reaction
Synonyms
diethyl-2-methyl-3-oxosuccinate reductase
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.229 - diethyl 2-methyl-3-oxosuccinate reductase
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REACTION DIAGRAM
dimethyl 2-methyl-3-oxosuccinate + NADPH
dimethyl 2-methyl-3-hydroxysuccinate + NADP+
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poor substrate
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additional information
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no aldehydes or several synthetic substrates are reduced, such as: acetaldehyde, formaldehyde, isobutanal, n-pentanal, n-hexanal, n-heptanal, 4-hydroxybenzaldehyde, 4-dimethylaminobenzaldehyde, benzaldehyde, furfural, 2-methyl-3-oxobutanoic acid benzyl ester, 2-chloro-3-oxobutanoic acid ethyl ester, 3-phenyl-2-oxobutanoic acid methyl ester, 2-methyl-3-oxobutanoic acid ethyl ester, 3-(2'-furyl)-2-methyl-3-oxopropionic acid methyl ester, none of the following alcohols or other substrates is oxidized: methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isopentanol, benzyl alcohol, glycerin, shikimic acid, 2-deoxy-D-glucose, glucose 6-phosphate, in the presence of NAD+ or NADP+
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diethyl 2-methyl-3-hydroxysuccinate + NADP+
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the reduction is strongly preferred, the catalyzed reaction is an asymmetric reduction, best substrate
alpha-methyl-beta-hydroxy ester, the enzyme catalyzes an asymmetric reduction, the product is a mixture of the (2R,3R)-syn- and (2S,3R)-anti-beta-hydroxyester
r
diethyl 2-methyl-3-oxosuccinate + NADPH
diethyl 2-methyl-3-hydroxysuccinate + NADP+
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asymmetric reduction in yeast, the reduction is strongly preferred over the weak oxidation activity
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