1.1.1.218: morphine 6-dehydrogenase

This is an abbreviated version!
For detailed information about morphine 6-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.218

Reaction

morphine
+
NAD(P)+
=
morphinone
+
NAD(P)H
+
H+

Synonyms

AKR1C34, M6DH, More, morphine 6-dehydrogenase, morphine-6-dehydrogenase, naloxone reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.218 morphine 6-dehydrogenase

General Information

General Information on EC 1.1.1.218 - morphine 6-dehydrogenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
physiological function
J7M9D0
mammalian morphine 6-dehydrogenase converts morphine into a reactive electrophile, morphinone. M6DH is involved in the toxic action of morphine including the development of tolerance to this drug