1.1.1.21: aldose reductase

This is an abbreviated version!
For detailed information about aldose reductase, go to the full flat file.

Reaction

Synonyms

17betaHSD5, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, AdhA, AKR1B, AKR1B1, AKR1B10, AKR1B13, AKR1B14, AKR1B3, AKR1C3, AKR4C7, aldehyde reductase, alditol/NADP+ oxidoreductase, alditol: NADP+ 1-oxidoreductase, alditol:NAD(P)+1oxidoreductase, alditol:NADP 1-oxidoreductase, alditol:NADP oxidoreductase, aldo-keto reductase, aldo-keto reductase family 1 member B1, aldo-keto reductase family 1 member B7, aldoketo reductase 1C3, aldose reductase, aldose reductase 2, aldose reductase-like, aldose reductase-like protein, aldose xylose reductase, ALDRXV4, ALR, ALR1, ALR2, AR, ARI, BAR, EC 1.1.1.139, Fibroblast growth factor regulated protein, FR-1 protein, GRE3, HAR, HRAR, isobutyraldehyde reductase, More, MVDP, NADPH dependent xylose reductase, NADPH-aldopentose reductase, NADPH-aldose reductase, polyol dehydrogenase (NADP2), RLAR, small intestine reductase, TPN-polyol dehydrogenase, VAS deferens androgen-dependent protein, YqhD

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.21 aldose reductase

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Results	in table
40	Activating Compound
317	AA Sequence
30	Application
1	CAS Registry Number
42	Cloned(Commentary)
145	Cofactor
31	Crystallization (Commentary)
5524	Disease/ Diagnostics
9	Expression
72	General Information
12	General Stability
719	IC50 Value
1440	Inhibitors
12	kcat/KM [mM/s]
64	Ki Value [mM]
286	KM Value [mM]
6	Localization
6	Metals/Ions
52	Molecular Weight [Da]
100	Natural Substrates/ Products (Substrates)
820	Organism
15	Pathway
196	PDB ID
65	pH Optimum
7	pH Range
6	pH Stability
2	pI Value
5	Posttranslational Modification
51	Protein Variants
55	Purification (Commentary)
10	Reaction
2	Reaction Type
248	Reference
238	Source Tissue
35	Specific Activity [micromol/min/mg]
7	Storage Stability
583	Substrates and Products (Substrate)
41	Subunits
261	Synonyms
1	Systematic Name
43	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
134	Turnover Number [1/s]

General Stability

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General Stability on EC 1.1.1.21 - aldose reductase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

-55°C, unstable to prolonged storage

Bos taurus

-

286246

25°C, 0.3 M phosphate or Tris, pH 6.0, more than 2 months

Yamadazyma tenuis

-

286260

alpha-crystallin stabilizes the enzyme with higher efficiency at 37°C compared to 25°C

Bos taurus

-

667331

dithiothreitol, 2 mM stabilizes, other sulfhydryl compounds such as beta-mercaptoethanol, glutathione and cysteine are less effective

Bos taurus

-

286248

DTT stabilizes the purified native enzyme from lens at 2 mM

Bos taurus

-

667224

enzyme is not stable unless dithiothreitol in micromolar range is present

Rattus norvegicus

-

656089

extremely labile to freezing and thawing unless Carbowax 100 is included, 10 mg/ml

Bos taurus

-

286243

freezing and thawing at temperatures above 50°C results in loss of activity

Homo sapiens

-

286241

freezing and thawing: more than twice, unstable

Bos taurus

-

286246

freezing of purified enzyme results in complete loss of activity

Homo sapiens

-

286186

needs Tween for stability during purification

Yamadazyma tenuis

-

286258

thiol stabilizing reagents are necessary

[Candida] intermedia

-

286259