1.1.1.207: (-)-menthol dehydrogenase

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For detailed information about (-)-menthol dehydrogenase, go to the full flat file.

Reaction

Synonyms

(-)-menthone:(3R)-menthol reductase, dehydrogenase, menthol, menthone:(-)-menthol reductase, MMR, monoterpenoid dehydrogenase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.207 (-)-menthol dehydrogenase

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Results	in table
6	AA Sequence
3	Application
1	CAS Registry Number
4	Cloned(Commentary)
4	Cofactor
2	Expression
1	General Information
4	Inhibitors
12	kcat/KM [mM/s]
17	KM Value [mM]
2	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
12	Organism
3	Pathway
3	pH Optimum
1	pH Range
1	Protein Variants
3	Purification (Commentary)
1	Reaction
3	Reaction Type
12	Reference
3	Source Tissue
20	Substrates and Products (Substrate)
7	Subunits
6	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
16	Turnover Number [1/s]

Engineering

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Engineering on EC 1.1.1.207 - (-)-menthol dehydrogenase

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additional information

Mentha x piperita

Q5CAF4

development of a one-pot (bio)synthesis of (1R,2S,5R)-(-)-menthol and (1S,2S,5R)-(+)-neomenthol from pulegone, using recombinant Escherichia coli extracts that contain the biosynthetic genes for an ene-reductase NtDBR from Nicotiana tabacum and two menthone dehydrogenases, MMR and MNMR from Mentha piperita, a modular engineering strategy to improve the final production level. Multigene-construct-derived enzyme mixtures production of menthone, isomenthone, menthol, and neomenthol, but no or poor production of neoisomenthol and isomenthol, overview

739778