1.1.1.201: 7beta-hydroxysteroid dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 7beta-hydroxysteroid dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

7beta-HSD, 7beta-HSDH, 7beta-hydroxysteroid dehydrogenase, More, NADP-dependent 7beta-hydroxysteroid dehydrogenase, RUMGNA_02585

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.201 7beta-hydroxysteroid dehydrogenase (NADP+)

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Results	in table
15	AA Sequence
5	Application
1	CAS Registry Number
6	Cloned(Commentary)
22	Cofactor
2	Crystallization (Commentary)
4	General Information
2	General Stability
2	Inhibitors
12	kcat/KM [mM/s]
39	KM Value [mM]
5	Localization
7	Molecular Weight [Da]
50	Natural Substrates/ Products (Substrates)
28	Organism
3	Pathway
2	PDB ID
12	pH Optimum
1	pH Range
19	Protein Variants
7	Purification (Commentary)
2	Reaction
3	Reaction Type
26	Reference
12	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
88	Substrates and Products (Substrate)
9	Subunits
32	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
7	Temperature Stability [°C]
17	Turnover Number [1/s]

Reference

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Reference on EC 1.1.1.201 - 7beta-hydroxysteroid dehydrogenase (NADP+)

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

286076

MacDonald, I.A.; Roach, P.D.

Bile induction of 7alpha- and 7beta-hydroxysteroid dehydrogenases in Clostridium absonum

Biochim. Biophys. Acta

665

262-269

1981

Clostridium sardiniense

6945134

brenda

286224

Macdonald, I.A.; Rochon, Y.P.; Hutchinson, D.M.; Holdeman, L.V.

Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7alpha-hydroxysteroid dehydrogenase-elaborating organisms

Appl. Environ. Microbiol.

44

1187-1195

1982

Collinsella aerofaciens

6758698

brenda

286226

Hirano, S.; Masuda, N.

Characterization of NADP-dependent 7beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens

Appl. Environ. Microbiol.

43

1057-1063

1982

Collinsella aerofaciens, Blautia producta

6954878

brenda

286227

Sutherland, J.D.; Williams, C.N.

Bile acid induction of 7alpha- and 7beta-hydroxysteroid dehydrogenases in Clostridium limosum

J. Lipid Res.

26

344-350

1985

Hathewaya limosa

3857290

brenda

286228

Edenharder, R.; Pfutzner, A.; Hammann, R.

Characterization of NAD-dependent 3alpha- and 3beta-hydroxysteroid dehydrogenase and of NADP-dependent 7beta-hydroxysteroid dehydrogenase from Peptostreptococcus productus

Biochim. Biophys. Acta

1004

230-238

1989

Blautia producta

2752021

brenda

286229

Edenharder, R.; Pfutzner, A.; Hammann, R.

NADP-dependent 3beta-, 7alpha- and 7beta-hydroxysteroid dehydrogenase activities from a lecithinase-lipase-negative Clostridium species 25.11.c

Biochim. Biophys. Acta

1002

37-44

1989

Clostridium sp., Clostridium sp. 25.11.c

2923864

brenda

656659

Shiotsuki, H.; Maeda, Y.; Chijiiwa, K.

Purification and characterization of 7beta-hydroxysteroid dehydrogenase from rabbit liver microsomes

J. Steroid Biochem. Mol. Biol.

91

185-190

2004

Oryctolagus cuniculus

15276626

brenda

724054

Liu, L.; Aigner, A.; Schmid, R.D.

Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7beta-hydroxysteroid dehydrogenase from Collinsella aerofaciens

Appl. Microbiol. Biotechnol.

90

127-135

2011

Collinsella aerofaciens, Collinsella aerofaciens DSM 3979

21181147

brenda

740787

Eggert, T.; Bakonyi, D.; Hummel, W.

Enzymatic routes for the synthesis of ursodeoxycholic acid

J. Biotechnol.

191

11-21

2014

Clostridium sardiniense, [Clostridium] scindens, Paeniclostridium sordellii, Collinsella aerofaciens, Fusarium equiseti

25131646

brenda

740835

Lee, J.Y.; Arai, H.; Nakamura, Y.; Fukiya, S.; Wada, M.; Yokota, A.

Contribution of the 7beta-hydroxysteroid dehydrogenase from Ruminococcus gnavus N53 to ursodeoxycholic acid formation in the human colon

J. Lipid Res.

54

3062-3069

2013

[Ruminococcus] gnavus (A7B4V1), [Ruminococcus] gnavus ATCC 29149 (A7B4V1)

23729502

brenda

741386

Savino, S.; Ferrandi, E.E.; Forneris, F.; Rovida, S.; Riva, S.; Monti, D.; Mattevi, A.

Structural and biochemical insights into 7beta-hydroxysteroid dehydrogenase stereoselectivity

Proteins

84

859-865

2016

Collinsella aerofaciens (A4ECA9), Collinsella aerofaciens ATCC 25986 (A4ECA9)

27006087

brenda

760289

Wang, R.; Wu, J.; Jin, D.K.; Chen, Y.; Lv, Z.; Chen, Q.; Miao, Q.; Huo, X.; Wang, F.

Structure of NADP+-bound 7beta-hydroxysteroid dehydrogenase reveals two cofactor-binding modes

Acta Crystallogr. Sect. F

73

246-252

2017

Collinsella aerofaciens, Collinsella aerofaciens ATCC 25986

28471355

brenda

760712

Zhang, X.; Fan, D.; Hua, X.; Zhang, T.

Large-scale production of ursodeoxycholic acid from chenodeoxycholic acid by engineering 7alpha- and 7beta-hydroxysteroid dehydrogenase

Bioprocess Biosyst. Eng.

42

1537-1545

2019

[Ruminococcus] torques, [Ruminococcus] torques ATCC 35915

31152232

brenda

761334

Zheng, M.M.; Chen, K.C.; Wang, R.F.; Li, H.; Li, C.X.; Xu, J.H.

Engineering 7beta-hydroxysteroid dehydrogenase for enhanced ursodeoxycholic acid production by multiobjective directed evolution

J. Agric. Food Chem.

65

1178-1185

2017

[Ruminococcus] torques, [Ruminococcus] torques ATCC 35915

28116898

brenda

Entries 1 - 20 of 14

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