1.1.1.201: 7beta-hydroxysteroid dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about 7beta-hydroxysteroid dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.1.1.201
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1.1.1.201
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synthesis
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ursodeoxycholic
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taurinates
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dehydrogenases
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nadph-dependent
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aerofaciens
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bile
- 1.1.1.201
- synthesis
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ursodeoxycholic
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taurinates
- dehydrogenases
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nadph-dependent
- aerofaciens
- bile
Reaction
Synonyms
7beta-HSD, 7beta-HSDH, 7beta-hydroxysteroid dehydrogenase, More, NADP-dependent 7beta-hydroxysteroid dehydrogenase, RUMGNA_02585
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.1.1.201 - 7beta-hydroxysteroid dehydrogenase (NADP+)
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REACTION DIAGRAM
3,7,12-triketo-5beta-cholanoic acid + NADPH
7beta-hydroxy-3,12-diketo-5beta-cholanoic acid + NADP+
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-
-
?
3,7,12-triketo-5beta-cholanoyl taurine + NADPH
7beta-hydroxy-3,12-diketo-5beta-cholanoyl taurine + NADP+
-
-
-
?
3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+
3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
3alpha,7beta-dihydroxy-5beta-cholanoyl glycine + NADP+
3alpha-hydroxy-7-keto-5beta-cholanoyl glycine + NADPH
3alpha,7beta-dihydroxy-5beta-cholanoyl taurine + NADP+
3alpha-hydroxy-7-keto-5beta-cholanoyl taurine + NADPH
3alpha-hydroxy-7,12-diketo-5beta-cholanoic acid + NADPH
3alpha,7beta-dihydroxy-12-keto-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NADPH + H+
3alpha,7beta-dihydroxy-5beta-cholan-24-oic acid + NADP+
7,12-diketo-5beta-cholanoic acid + NADPH
7beta-hydroxy-12-keto-5beta-cholanoic acid + NADP+
7beta-hydroxy-3-keto-5beta-cholanoic acid + NADP+
-
-
-
?
3,7-diketo-5beta-cholanoic acid + NADPH
7beta-hydroxy-3-keto-5beta-cholanoic acid + NADP+
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-
-
?
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+
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-
-
?
3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+
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-
-
?
3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
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partially reversible, poor substrate
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r
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+
3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
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ursocholic acid
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r
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+
3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
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ursocholic acid
-
?
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
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ursodeoxycholic acid
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?
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
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ursodeoxycholic acid
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?
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
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only active on free and conjugated bile salts
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?
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
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ursodeoxycholic acid
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?
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
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ursodeoxycholic acid
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?
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
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activity only in the reductive reaction
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-
ir
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
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activity only in the reductive reaction
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-
ir
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
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ursodeoxycholic acid
-
?
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
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ursodeoxycholic acid
-
r
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
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partially reversible
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r
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
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only active on free and conjugated bile salts
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?
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
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ursodeoxycholic acid
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?
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
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active on both free and conjugated bile salts
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?
3alpha-hydroxy-7-keto-5beta-cholanoyl glycine + NADPH
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-
-
?
3alpha,7beta-dihydroxy-5beta-cholanoyl glycine + NADP+
3alpha-hydroxy-7-keto-5beta-cholanoyl glycine + NADPH
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-
-
?
3alpha-hydroxy-7-keto-5beta-cholanoyl taurine + NADPH
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-
-
?
3alpha,7beta-dihydroxy-5beta-cholanoyl taurine + NADP+
3alpha-hydroxy-7-keto-5beta-cholanoyl taurine + NADPH
-
-
-
?
3alpha,7beta-dihydroxy-5beta-cholanoyl taurine + NADP+
3alpha-hydroxy-7-keto-5beta-cholanoyl taurine + NADPH
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partially reversible, poore substrate
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r
3alpha,7beta-dihydroxy-12-keto-5beta-cholanoic acid + NADP+
-
-
-
?
3alpha-hydroxy-7,12-diketo-5beta-cholanoic acid + NADPH
3alpha,7beta-dihydroxy-12-keto-5beta-cholanoic acid + NADP+
-
-
-
?
3alpha,7beta-dihydroxy-5beta-cholan-24-oic acid + NADP+
i.e. 7-oxo-lithocholic acid
i.e. ursodeoxycholic acid
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r
3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NADPH + H+
3alpha,7beta-dihydroxy-5beta-cholan-24-oic acid + NADP+
i.e. 7-oxo-lithocholic acid
i.e. ursodeoxycholic acid
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r
7beta-hydroxy-12-keto-5beta-cholanoic acid + NADP+
-
-
-
?
7,12-diketo-5beta-cholanoic acid + NADPH
7beta-hydroxy-12-keto-5beta-cholanoic acid + NADP+
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-
-
?
7-oxosteroid + NADPH + H+
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-
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r
7beta-hydroxysteroid + NADP+
7-oxosteroid + NADPH + H+
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-
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r
ursodeoxycholic acid + NADP+
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-
-
-
?
chenodeoxycholic acid + NADPH + H+
ursodeoxycholic acid + NADP+
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-
-
-
?
chenodeoxycholic acid + NADPH + H+
ursodeoxycholic acid + NADP+
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-
-
-
?
chenodeoxycholic acid + NADPH + H+
ursodeoxycholic acid + NADP+
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-
-
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?
ursodeoxycholic acid + NADP+
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presence of both 7alpha-HSDH (EC 1.1.1.159) and 7beta-HSDH in one organism allows epimerization by a single bacterium
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?
lithocholic acid + NADPH + H+
ursodeoxycholic acid + NADP+
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-
-
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?
7-oxo-lithocholic acid + NADPH + H+
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-
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r
ursodeoxycholic acid + NADP+
7-oxo-lithocholic acid + NADPH + H+
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-
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r
?
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in vivo, the forward reaction that produces ursodeoxycholic acid from 7-oxo-lithocholic acid is observed to have a growth-dependent conversion rate of 90-100% after culture in anaerobic medium broth containing 1 mM 7-oxo-lithocholic acid, while the reverse reaction is undetectable. The purified 7beta-HSDH shows a kcat/Km value that is about 55fold higher for the forward reaction than for the reverse reaction, indicating that the enzyme favors the UDCA producing reaction
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?
additional information
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in vivo, the forward reaction that produces ursodeoxycholic acid from 7-oxo-lithocholic acid is observed to have a growth-dependent conversion rate of 90-100% after culture in anaerobic medium broth containing 1 mM 7-oxo-lithocholic acid, while the reverse reaction is undetectable. The purified 7beta-HSDH shows a kcat/Km value that is about 55fold higher for the forward reaction than for the reverse reaction, indicating that the enzyme favors the UDCA producing reaction
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?