1.1.1.193: 5-amino-6-(5-phosphoribosylamino)uracil reductase

This is an abbreviated version!
For detailed information about 5-amino-6-(5-phosphoribosylamino)uracil reductase, go to the full flat file.

Reaction

5-amino-6-(5-phospho-D-ribitylamino)uracil
+
NADP+
=
5-amino-6-(5-phospho-D-ribosylamino)uracil
 +
NADPH
 +
H+

Synonyms

aminodioxyphosphoribosylaminopyrimidine reductase, HTP reductase, Rib7, RibD, RibG, riboflavin biosynthesis protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.193 5-amino-6-(5-phosphoribosylamino)uracil reductase

Engineering

Engineering on EC 1.1.1.193 - 5-amino-6-(5-phosphoribosylamino)uracil reductase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K151A
-
inactive
K151D
-
inactive
K151E
-
inactive
D33A
-
the mutant shows 0.1-0.6% activity compared to the wild type enzyme
D33K
-
inactive
D33N
-
inactive
D57N
-
the mutant shows 0.1-0.6% activity compared to the wild type enzyme
E156Q
-
inactive
N9A
-
the mutant shows 0.1-0.6% activity compared to the wild type enzyme
R91A
-
the mutation eliminates the endogenous NADPH binding and switches preference of the enzyme to NADH
S29A
-
the mutant shows 0.1-0.6% activity compared to the wild type enzyme
S88E
-
the mutation eliminates the endogenous NADPH binding and switches preference of the enzyme to NADH
additional information