1.1.1.187: GDP-4-dehydro-D-rhamnose reductase

This is an abbreviated version, for detailed information about GDP-4-dehydro-D-rhamnose reductase, go to the full flat file.

Reaction

GDP-alpha-D-rhamnose
+
NAD(P)+
=
GDP-4-dehydro-alpha-D-rhamnose
+
NAD(P)H
+
H+

Synonyms

GDP KR reductase, GDP-4-keto-6-deoxy-D-mannose reductase, GDP-4-keto-D-rhamnose reductase, guanosine diphosphate-4-keto-D-rhamnose reductase, RMD, tld gene product

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.187 GDP-4-dehydro-D-rhamnose reductase

Engineering

Engineering on EC 1.1.1.187 - GDP-4-dehydro-D-rhamnose reductase

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ENGINEERING
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UNIPROT
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LITERATURE
additional information
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construction of enzyme deletion mutant DELTArmd. The mutant strain shows highly reduced antimicrobial susceptibility with chloramphenicol, ampicillin or spectinomycin. Structural analysis of lipopolysaccharides in the mutant strain, NMR and mass spectrrometry analysis, overview