1.1.1.184: carbonyl reductase (NADPH)

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For detailed information about carbonyl reductase (NADPH), go to the full flat file.

Reaction

Synonyms

(R) specific carbonyl reductase, (S)-specific carbonyl reductase, 15-hydroxyprostaglandin dehydrogenase [NADP+], 2,5-diketo-D-gluconic acid reductase, Adipocyte P27 protein, aldehyde reductase 1, aldehyde reductase I, aldo-keto reductase, ALR3, AP27, carbonyl reductase, carbonyl reductase (NADPH), carbonyl reductase 1, carbonyl reductase 3, carbonyl reductase S1, CBR, CBR 1, CBR 3, CBR1, CBR3, CHCR, CHCR1, CHCR2, CHCR3, CR, CR125, crc1, CSCR1, Gox0644, Gox1615, hCBR1, ketoreductase, KLCR1, KR, LCR, LOC415661, LOC610164, microsomal carbonyl reductase, More, NADP+-dependent ADH, NADPH-carbonyl reductase, NADPH-dependent carbonyl reductase, NADPH-dependent carbonyl reductase S1, NCCR, nonspecific NADPH-dependent carbonyl reductase, peroxisomal-type carbonyl reductase, PHCR, prostaglandin 9-ketoreductase, Prostaglandin-E2 9-reductase, PTCR, R-specific carbonyl reductase, reductase S1, reductase, carbonyl, RLCR, SCR, SCR9, SDR21C1, secondary-alcohol: NADP+-oxidoreductase, short-chain (S)-1-phenyl-1,2-ethanediol dehydrogenase, short-chain carbonyl reductase, sniffer, SRED, SSCR, SyS1, tetrameric carbonyl reductase, Tm1743, Tm_1743, xenobiotic carbonyl reductase, xenobiotic ketone reductase, YGL039w1, YGL039w2, YtbE, YueD

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.184 carbonyl reductase (NADPH)

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Results	in table
8	Activating Compound
2197	AA Sequence
26	Application
3	CAS Registry Number
74	Cloned(Commentary)
93	Cofactor
18	Crystallization (Commentary)
221	Disease/ Diagnostics
4	Expression
15	General Information
6	General Stability
45	IC50 Value
263	Inhibitors
74	kcat/KM [mM/s]
15	Ki Value [mM]
380	KM Value [mM]
22	Localization
30	Metals/Ions
90	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
21	Organic Solvent Stability
295	Organism
6	Pathway
31	PDB ID
47	pH Optimum
10	pH Range
8	pH Stability
2	pI Value
2	Posttranslational Modification
64	Protein Variants
58	Purification (Commentary)
9	Reaction
3	Reaction Type
162	Reference
105	Source Tissue
143	Specific Activity [micromol/min/mg]
8	Storage Stability
832	Substrates and Products (Substrate)
88	Subunits
189	Synonyms
1	Systematic Name
38	Temperature Optimum [°C]
8	Temperature Range [°C]
22	Temperature Stability [°C]
209	Turnover Number [1/s]

pH Stability

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pH Stability on EC 1.1.1.184 - carbonyl reductase (NADPH)

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3 - 11.5

Aeropyrum pernix

Q9Y8Y1

-

740396

4.4

Cavia porcellus

-

unstable

347750

4.5 - 7.5

Scheffersomyces stipitis

A3GF07

4°C, maintains more than 80% of maximum activity for 48 h

711492

5.5

Pichia kudriavzevii

-

highest stability

725727

5.5 - 7.5

[Candida] boidinii

-

the enzyme is highly stable in acidic environment and more than 80% of the activity is maintained when exposed to pH 5.5-7.5 for 60 min at 25°C

760245

6 - 11

Cavia porcellus

-

25°C, 15 min, stable

347750

6.5 - 9

Gallus gallus

F1N9C1

10 min, 40°C, at least 50% residual activity

740436

9

Bacillus subtilis

-

the enzyme keeps more than 70% of its peak activity after incubation in Tris-HCl buffer at pH 9.0 for 40 h

760815