1.1.1.18: inositol 2-dehydrogenase
This is an abbreviated version!
For detailed information about inositol 2-dehydrogenase, go to the full flat file.
Reaction
Synonyms
BsIDH, cg0204, GK1898, IDH, inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase, inositol dehydrogenase, iolG, iolG1, iolG2, LcIDH1, LcIDH2, MI dehydrogenase, More, myo-inositol 2-dehydrogenase, myo-inositol dehydrogenase, myo-inositol:NAD2 oxidoreductase
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 1.1.1.18 - inositol 2-dehydrogenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
(1S,2S,3R,4S,5S)-5-(allyloxy)cyclohexane-1,2,3,4-tetrol + NAD+
?
-
-
-
?
(1S,2S,3R,4S,5S)-5-(benzyloxy)cyclohexane-1,2,3,4-tetrol + NAD+
?
-
-
-
?
(1S,2S,3R,4S,5S)-5-methoxycyclohexane-1,2,3,4-tetrol + NAD+
?
-
-
-
?
4-([[(1S,2S,3R,4S,5S)-2,3,4,5-tetrahydroxycyclohexyl]oxy]methyl)benzoic acid + NAD+
?
-
-
-
?
4-O-((1S)-10-camphor-sulfonyl)-myo-inositol + NAD+
? + NADH + H+
-
-
-
?
4-O-((4-methyloxycarbonyl)-benzyl)-myo-inositol + NAD+
? + NADH + H+
-
-
-
?
4-O-alpha-D-glucopyranosyl-myo-inositol + NAD+
? + NADH + H+
-
-
-
?
4-O-[(2-methylphenyl)methyl]-myo-inositol + NAD+
? + NADH + H+
-
-
-
?
4-O-[(3-methylphenyl)methyl]-myo-inositol + NAD+
? + NADH + H+
-
-
-
?
alpha-D-glucopyranose + NAD+
D-gluconate + NADH
-
4fold lower activity compared to myo-inositol as substrate, does not act with the beta-anomer
-
?
D-2,3-diketo-4-deoxy-epi-inositol + NADH
ketodeoxyinositol + NAD+
-
-
-
?
D-chiro-inositol + NAD+
? + NADH
-
19% of the activity with myo-inositol
-
-
?
epi-inositol + NAD+
epi-inosose + NADH
-
5% of the activity compared to myo-inositol as substrate, conversion of epi-inosose 5% of the activity compared to scyllo-inosose as substrate
-
r
methyl 4-([[(1S,2S,3R,4S,5S)-2,3,4,5-tetrahydroxycyclohexyl]oxy]methyl)benzoate + NAD+
?
-
-
-
?
myo-inositol + 2,6-dichlorophenolindophenol
2,4,6/3,5-pentahydroxycyclohexanone + reduced 2,6-dichlorophenolindophenol
-
-
-
?
scyllo-inositol + NAD+
scyllo-inosose + NADH
-
5% of the activity compared to myo-inositol as substrate
-
?
D-glucose + NAD+
D-gluconate + NADH
9% of the activity compared to myo-inositol as substrate
-
?
D-xylose + NAD+
? + NADH
7% of the activity compared to myo-inositol as substrate
-
?
2,3,4,5,6-pentahydroxycyclohexanone + NADH + H+
-
-
-
-
r
myo-inositol + NAD+
2,3,4,5,6-pentahydroxycyclohexanone + NADH + H+
-
-
-
-
r
2,4,6/3,5-pentahydroxycyclohexanone + NADH
-
-
-
?
myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
-
-
?
myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
-
-
-
?
myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
-
-
-
?
myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
-
should be classified as A-type enzyme
-
?
myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
-
-
-
?
myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
involved in nitrogen fixation and nodulation of soybean
-
?
myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
involved in nitrogen fixation and nodulation of soybean
-
?
myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
involved in rhizopine utilization
-
?
myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
-
-
-
?
2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
i.e. scyllo-inosose
-
?
myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
-
-
r
myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
-
-
?
myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
i.e. scyllo-inosose
-
?
myo-inositol + NAD+
scyllo-inosose + NADH
-
first enzyme in the catabolic pathway of myo-inositol
-
-
r
myo-inositol + NAD+
scyllo-inosose + NADH
-
oxidation of the axial hydroxyl group of myo-inositol
-
-
r
myo-inositol + NAD+
scyllo-inosose + NADH
-
75 times lower activity compared to the reverse reaction
-
r
myo-inositol + NAD+
scyllo-inosose + NADH + H+
-
the NAD+-dependent enzyme catalyses the oxidation of the axial hydroxyl group of myo-inositol to form scyllo-inosose
-
-
?
?
-
i.e. 3-O-methyl-D-chiro-inositol. Bacillus subtilis can utilize pinitol as the sole carbon source via the same myo-inositol catabolic pathway
-
-
?
pinitol + NADH + H+
?
-
i.e. 3-O-methyl-D-chiro-inositol. Bacillus subtilis can utilize pinitol as the sole carbon source via the same myo-inositol catabolic pathway
-
-
?
?
-
a nonpolar cavity adjacent to the active site, allows racemic protected inositol derivatives such as 4-O-benzyl-myo-inositol to be recognized with very high stereoselectivity. Trace activity with (1S,2S,3R,4S,5S)-2,3,4,5-tetrahydroxycyclohexyl dihydrogen phosphate
-
-
?
additional information
?
-
-
a nonpolar cavity adjacent to the active site, allows racemic protected inositol derivatives such as 4-O-benzyl-myo-inositol to be recognized with very high stereoselectivity. Trace activity with (1S,2S,3R,4S,5S)-2,3,4,5-tetrahydroxycyclohexyl dihydrogen phosphate
-
-
?
additional information
?
-
substrate specificity and substrate binding structure, molecular modeling, overview
-
-
?
additional information
?
-
-
substrate specificity and substrate binding structure, molecular modeling, overview
-
-
?
additional information
?
-
-
the enzyme shows a broad substrate spectrum while remaining highly stereoselective. BsIDH is able to oxidize the mono-saccharides alpha-D-glucose and alpha-D-xylose but not beta-D-glucose, D-mannose and D-galactose
-
-
?
additional information
?
-
-
scyllo-inositol is no substrate for the enzyme, thus IolG does not act as a scyllo-inositol dehydrogenase
-
-
?
additional information
?
-
-
scyllo-inositol is no substrate for the enzyme, thus IolG does not act as a scyllo-inositol dehydrogenase
-
-
?