1.1.1.159: 7alpha-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 7alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.159

1.1.1.159

chenodeoxycholic

cholic

testosteroni

bacteroides

thin-layer

3alpha-hydroxysteroid

synthesis

fragilis

7alpha-oh

glycochenodeoxycholic

nadp-dependent

ursodeoxycholic

perfringens

degradation

analysis

Reaction

3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate

Synonyms

7-alpha-HSDH, 7-HSDH, 7alpha-HSD, 7alpha-HSDH, 7alpha-hydroxy steroid dehydrogenase, 7alpha-hydroxysteroid dehydrogenase, Bile acid-inducible protein, CA 7alpha-HSDH, Ca7alpha-HSDH, dehydrogenase, 7alpha-hydroxy steroid, J-1-1, NADP(H)-dependent 7alpha-HSDH, NADP(H)-dependent 7alpha-hydroxysteroid dehydrogenase, NADP+-dependent 7alpha-HSDH, nicotinamide adenine dinucleotide phosphate-dependent 7alpha-hydroxysteroid dehydrogenase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.159 7alpha-hydroxysteroid dehydrogenase

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Results	in table
9	Activating Compound
1020	AA Sequence
8	Application
1	CAS Registry Number
13	Cloned(Commentary)
40	Cofactor
4	Crystallization (Commentary)
12	General Information
4	General Stability
37	Inhibitors
13	kcat/KM [mM/s]
61	KM Value [mM]
10	Metals/Ions
16	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
57	Organism
3	Pathway
26	PDB ID
16	pH Optimum
3	pH Range
4	pH Stability
1	pI Value
33	Protein Variants
17	Purification (Commentary)
4	Reaction
3	Reaction Type
45	Reference
2	Source Tissue
31	Specific Activity [micromol/min/mg]
4	Storage Stability
133	Substrates and Products (Substrate)
15	Subunits
38	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
15	Temperature Stability [°C]
24	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 1.1.1.159 - 7alpha-hydroxysteroid dehydrogenase

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Escherichia coli

oxidation of cholic acid

286083

10.5

Brevibacterium fuscum

oxidation of cholic acid

286075

5.3

Brevibacterium fuscum

dehydrocholic acid reduction

6.5

NADH oxidation

assay at

7 - 9

NADP+-dependent activity

286079

7.5

Stenotrophomonas maltophilia

670898

8.5

2 entries

8.5 - 9

Bacteroides fragilis

oxidation of 7alpha-hydroxy group

286078

Clostridium sardiniense

G9FRD7

760375

9 - 10

Escherichia coli

oxidation of cholic acid

9.4 - 9.6

9.5 - 10

NAD+-dependent activity

286079

9.5 - 10.5

Clostridium sardiniense

286076

additional information

Brevibacterium fuscum

value for reduction of dehydrocholic acid below 5.2, not measurable due to insolubility of substrate

286075