1.1.1.159: 7alpha-hydroxysteroid dehydrogenase
This is an abbreviated version!
For detailed information about 7alpha-hydroxysteroid dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.159
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1.1.1.159
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chenodeoxycholic
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cholic
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testosteroni
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bacteroides
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thin-layer
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3alpha-hydroxysteroid
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synthesis
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fragilis
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7alpha-oh
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glycochenodeoxycholic
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nadp-dependent
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ursodeoxycholic
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perfringens
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degradation
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analysis
- 1.1.1.159
-
chenodeoxycholic
-
cholic
- testosteroni
- bacteroides
-
thin-layer
-
3alpha-hydroxysteroid
- synthesis
- fragilis
-
7alpha-oh
-
glycochenodeoxycholic
-
nadp-dependent
-
ursodeoxycholic
- perfringens
- degradation
- analysis
Reaction
Synonyms
7-alpha-HSDH, 7-HSDH, 7alpha-HSD, 7alpha-HSDH, 7alpha-hydroxy steroid dehydrogenase, 7alpha-hydroxysteroid dehydrogenase, Bile acid-inducible protein, CA 7alpha-HSDH, Ca7alpha-HSDH, dehydrogenase, 7alpha-hydroxy steroid, J-1-1, NADP(H)-dependent 7alpha-HSDH, NADP(H)-dependent 7alpha-hydroxysteroid dehydrogenase, NADP+-dependent 7alpha-HSDH, nicotinamide adenine dinucleotide phosphate-dependent 7alpha-hydroxysteroid dehydrogenase
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General Information
General Information on EC 1.1.1.159 - 7alpha-hydroxysteroid dehydrogenase
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evolution
malfunction
physiological function
additional information
7alpha-HSDHs is a member of SDR superfamily and belongs to the classical subfamily with the cofactor binding site sequence motif TA/G/SxxxGIG and the active site sequence motif YxxxK (x = any amino acid residue)
evolution
7alpha-hydroxysteroid dehydrogenase is a member of the short-chain dehydrogenase/reductase superfamily
evolution
the enzyme is a member of the short-chain dehydrogenase/reductase (SDR) superfamily
evolution
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the enzyme is a member of the short-chain dehydrogenase/reductase (SDR) superfamily
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a 7alpha -HSD knockout mutant shows decreased degradation of testosterone, estradiol and cholesterol compared to the wild-type
malfunction
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a 7alpha -HSD knockout mutant shows decreased degradation of testosterone, estradiol and cholesterol compared to the wild-type
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the enzyme CA 7alpha-HSDH is responsible for reversibly catalysing the oxidation of C7alpha-oriented hydroxyl of the steroid nucleus in the bile acid metabolism
physiological function
the enzyme catalyzes the dehydrogenation of C7 hydroxyl group of the steroid skeleton of bile acids
molecular dynamics simulation of cofactor NADPH and taurochenodeoxycholic acid bound to the enzyme, overview. The C-terminal structure of CA 7alpha-HSDH does not directly surround the substrate-binding pocket but stretch outward. The Ser-Tyr-Lys triad is well conserved in other 7alpha-HSDHs but not in the CA 7alpha-HSDH
additional information
the C-terminus and residue Arg38 are essential for activity of the 7alpha-hydroxysteroid dehydrogenase from Clostridium absonum
additional information
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the C-terminus and residue Arg38 are essential for activity of the 7alpha-hydroxysteroid dehydrogenase from Clostridium absonum
additional information
the enzyme sequence contains a Tyr-X-X-X-Lys segment, residues 161-165, that is essential for catalytic activity of SDR proteins
additional information
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the enzyme sequence contains a Tyr-X-X-X-Lys segment, residues 161-165, that is essential for catalytic activity of SDR proteins
additional information
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the enzyme sequence contains a Tyr-X-X-X-Lys segment, residues 161-165, that is essential for catalytic activity of SDR proteins
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