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1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

This is an abbreviated version!
For detailed information about sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), go to the full flat file.

Word Map on EC 1.1.1.153

Reaction

L-erythro-7,8-dihydrobiopterin
+
NADP+
=
sepiapterin
 +
NADPH
 +
H+

Synonyms

AKR1B1, MDSPI16 protein, MDSPR, reductase, sepiapterin, sepiapterin reductase, SPR, SR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

Source Tissue

Source Tissue on EC 1.1.1.153 - sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
monoaminergic field, neurons
Manually annotated by BRENDA team
-
post-mortem semi-quantitative expression analysis in brain of control individuals and Parkinson disease patients, SPR expression is increased in Parkinson patients, but not in the other genes involved in the tetrahydrobiopterin biosynthesis, overview
Manually annotated by BRENDA team
-
neurons
Manually annotated by BRENDA team
-
dorsal and ventral parts
Manually annotated by BRENDA team
-
no enzyme detectable
Manually annotated by BRENDA team
larval, high enzyme level
Manually annotated by BRENDA team
SPR mRNA expression is highest in all neuroblastoma clinical groups with poor outcome
Manually annotated by BRENDA team
-
neurons
Manually annotated by BRENDA team
additional information