1.1.1.149: 20alpha-hydroxysteroid dehydrogenase
This is an abbreviated version!
For detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.149
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1.1.1.149
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progesterone
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androgen
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prostate
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reductases
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testosterone
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prostaglandin
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akr1cs
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steroidogenic
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luteal
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castration-resistant
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srd5a1
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androstenedione
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5alpha-reductase
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cyp17a1
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dihydrotestosterone
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progestin
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akr1b10
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17beta-hydroxysteroid
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3alpha-hsds
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abiraterone
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neurosteroids
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luteolysis
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hsd3b1
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5alpha-dihydrotestosterone
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17beta-hsds
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enzalutamide
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flufenamic
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17beta
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ketosteroid
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allopregnanolone
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3beta-hsd
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17alpha
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17alpha-hydroxyprogesterone
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hydrogenans
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pgf2alpha
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hsd17b3
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pre-receptor
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intracrine
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3-ketosteroids
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dihydrodiol
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scarb1
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analysis
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biotechnology
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food industry
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medicine
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environmental protection
- 1.1.1.149
- progesterone
- androgen
- prostate
- reductases
- testosterone
- prostaglandin
- akr1cs
-
steroidogenic
- luteal
-
castration-resistant
- srd5a1
- androstenedione
-
5alpha-reductase
- cyp17a1
- dihydrotestosterone
- progestin
- akr1b10
-
17beta-hydroxysteroid
- 3alpha-hsds
- abiraterone
-
neurosteroids
-
luteolysis
- hsd3b1
- 5alpha-dihydrotestosterone
- 17beta-hsds
-
enzalutamide
-
flufenamic
-
17beta
- ketosteroid
- allopregnanolone
- 3beta-hsd
-
17alpha
- 17alpha-hydroxyprogesterone
-
hydrogenans
-
pgf2alpha
- hsd17b3
-
pre-receptor
-
intracrine
- 3-ketosteroids
- dihydrodiol
-
scarb1
- analysis
- biotechnology
- food industry
- medicine
- environmental protection
Reaction
Synonyms
20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, 20beta-HSDH, 20beta-hydroxysteroid dehydrogenase, 3alpha-HSOR, 3alpha-hydroxysteroid oxidoreductase, AKR1C1, AKR1C14, AKR1C23, AKR1C3, AKR1C5, AKR1C9, aldo-keto reductase family 1 member C1, HSD1, More
ECTree
1.1.1.149 20alpha-hydroxysteroid dehydrogenaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
17alpha-hydroxyprogesterone + NAD(P)H
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inactive molecule form
hormone
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r
daunorubicin + NADPH + H+
daunorubicinol + NADP+
inactivation of the anticancer drug
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-
r
progesterone + NAD(P)H
20alpha-hydroxypregn-4-en-3-one + NAD(P)+
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-
-
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r
progesterone + NAD(P)H + H+
20alpha-hydroxyprogesterone + NAD(P)+
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maternal and fetal 20alpha-HSD play a role in maintaining normal pregnancy at least partially by reducing progesterone concentrations in fetuses
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?
17alpha-hydroxyprogesterone + NAD(P)H
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
the aldo-keto reductase, AKR1C23, also shows 20alpha-hydroxysteroid dehydrogenase activity in vivo, enzyme regulation in preovulatory follicles and corpora lutea, overview
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r
17alpha-hydroxyprogesterone + NAD(P)H
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
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-
-
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r
17alpha-hydroxyprogesterone + NAD(P)H
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
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the enzyme activity is highest in women with visceral obesity
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r
17alpha-hydroxyprogesterone + NAD(P)H
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
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NADPH is preferred to NADH in liver, while the kidney enzyme is specific for NADPH
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-
r
17alpha-hydroxyprogesterone + NAD(P)H
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
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progesterone catabolism
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r
17alpha-hydroxyprogesterone + NAD(P)H
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
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regulation of enzyme expression during pregnancy, the enzyme is required for prostaglandin F2alpha-dependent progesterone down-regulation before parturition, overview
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r
17alpha-hydroxyprogesterone + NAD(P)H
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
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progesterone catabolism
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-
r
17alpha-hydroxyprogesterone + NAD(P)H
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
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-
-
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r
5alpha-dihydroprogesterone + NADPH + H+
5alpha,20alpha-tetrahydroprogesterone + NADP+
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-
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r
5alpha-dihydroprogesterone + NADPH + H+
5alpha,20alpha-tetrahydroprogesterone + NADP+
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-
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r
5alpha-dihydroprogesterone + NADPH + H+
5alpha,20alpha-tetrahydroprogesterone + NADP+
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-
-
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r
cortisol + NADH + H+
20beta-hydroxycortisol + NAD+
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-
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?
cortisol + NADH + H+
20beta-hydroxycortisol + NAD+
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-
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?
dihydrotestosterone + NADPH + H+
4-androsten-3alpha,17beta-diol + NADP+
reaction of EC 1.1.1.357
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r
dihydrotestosterone + NADPH + H+
4-androsten-3alpha,17beta-diol + NADP+
reaction of EC 1.1.1.357
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r
dihydrotestosterone + NADPH + H+
4-androsten-3alpha,17beta-diol + NADP+
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reaction of EC 1.1.1.357
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r
progesterone + NADPH
20alpha-hydroxyprogesterone + NADP+
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central role in luteolysis and parturition
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?
additional information
?
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pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview
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-
?
additional information
?
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pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview
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-
?
additional information
?
-
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role of enzyme suggested to be for detoxication or metabolism of carbonyl compounds because of broad substrate specificity
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-
?
additional information
?
-
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role of enzyme suggested to be for detoxication or metabolism of carbonyl compounds because of broad substrate specificity
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-
?
additional information
?
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-
role of enzyme suggested to be for detoxication or metabolism of carbonyl compounds because of broad substrate specificity
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-
?
