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1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.149

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
 +
NAD(P)H
 +
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, 20beta-HSDH, 20beta-hydroxysteroid dehydrogenase, 3alpha-HSOR, 3alpha-hydroxysteroid oxidoreductase, AKR1C1, AKR1C14, AKR1C23, AKR1C3, AKR1C5, AKR1C9, aldo-keto reductase family 1 member C1, HSD1, More

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

Expression

Expression on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
20alpha-HSD mRNA is higher expressed in the ovary at pre-ovulation than in the placenta and oviduct at pre-parturition
-
human immunodeficiency virus-infected pregnant women receiving protease inhibitor-based combination antiretroviral therapy show an elevation in placental expression of the 20-alpha-hydroxysteroid dehydrogenase
-
mRNA levels increase gradually throughout the estrous cycle, the highest being in the corpus luteum (CL) 1 stage
-
no difference in endometrial enzyme expression is detected between induced short and normal cycles in dairy cows treated with prostaglandin F2alpha and gonadotrophin-releasing hormone 24 h apart
-
placental enzyme expression is significantly elevated in human immunodeficiency virus-infected pregnant women exposed to protease inhibitor-based combination antiretroviral therapy
-
the amount of enzyme mRNA in cultured luteal cells increases with time and by treatment with the luteolysis agent prostaglandin F2alpha
the enzyme expression is upregulated by daunorubicin treament
the protein is detected in the testes 1 week after birth and increases dramatically at 8 weeks