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1.1.1.146: 11beta-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 11beta-hydroxysteroid dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.146

Reaction

an 11beta-hydroxysteroid
+
NADP+
=
an 11-oxosteroid
+
NADPH
+
H+

Synonyms

11 beta-hydroxysteroid dehydrogenase type 1, 11-beta hydroxysteroid dehydrogenase type 1, 11-beta-HSD1, 11-beta-HSD1 (oxidase) NADP+, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type1, 11-DH, 11-DH2, 11-oxoreductase, 11beta hydroxysteroid dehydrogenase type 1, 11beta-HSD, 11beta-HSD 1, 11beta-HSD type 1, 11beta-HSD-1, 11beta-HSD-2, 11beta-HSD1, 11beta-HSD1A, 11beta-HSD2, 11beta-hydroxy steroid dehydrogenase, 11beta-hydroxy steroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase 1, 11beta-hydroxysteroid dehydrogenase 2, 11beta-hydroxysteroid dehydrogenase isoforms 1, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type I, 11beta-hydroxysteroid dehydrogenase type-1, 11beta-hydroxysteroid dehydrogenase-1, 11beta-hydroxysteroid dehydrogenases type 1, 11beta-hydroxysteroid type 1 dehydrogenase, 11beta-hydroxysteroid-dehydrogenase type I, 11betaHSD1, 11betaHSD2, 11HSD1, beta-hydroxysteroid dehydrogenase, corticosteroid 11-reductase, corticosteroid 11beta-dehydrogenase, dehydrogenase, 11beta-hydroxy steroid, HSD1, HSD11B, HSD11B1, Hsd11B2, HSD2, hydroxysteroid (11-beta) dehydrogenase, isozyme 11beta-HSD1, More, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, NADP(+)-dependent 11beta-dehydrogenase, NADP+-dependent 11beta-hydroxysteroid dehydrogenase 1, type 1 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.146 11beta-hydroxysteroid dehydrogenase

Expression

Expression on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
administration of human chorionic gonadotropin during prespawning and resting phases reveals initial rise in 11beta-HSD2 transcript at 4 h followed by gradual increase at 8 h, 12 h and peaking at 24 h, only in testis of prespawning phase
-
continuous exposure to glucocorticoid indirectly inhibits the activity of isoform 11beta-HSD1
-
enzyme expression of isoform 11beta-HSD2 is dysregulated in malignant cells
epidermal isoform 11beta-HSD1 expression is decreased in the lesional skin of patients with atopic dermatitis
expression of isoform 11beta-HSD1 is induced by UV-B irradiation and in response to the pro-inflammatory cytokines, interleukin-1beta and tumor necrosis factor alpha
-
isoform 11beta-HSD1 enzyme activity is decreased in diabetic subjects
isoform 11beta-HSD1 expression does not vary in patients with inflammatory bowel disease compared with controls
isoform 11beta-HSD1 mRNA expression and enzyme activity is up-regulated by physiological concentrations of cortisol. After treatment with dexamethasone, isoform 11beta-HSD1 mRNA expression increases in both diabetics and controls
isoform 11beta-HSD2 expression is downregulated in patients with inflammatory bowel disease compared with controls
isozyme 11beta-HSD1, expression analysis
-
isozyme expression analysis
larvae reared at male-producing temperature, and cortisol treatment produce significant increases in isoform Hsd11B2 mRNA expression. Also, gonadal explants incubated in the presence of cortisol show increases of 11-ketotestosterone levels in the medium
-
short-term exposure to glucocorticoid increases the activity of isoform 11beta-HSD1
-
stress stimulates isoform 11HSD1 expression in the ventral hippocampus
-
the enzyme activity is increased 3-4fold in the adrenal glands in the course of development of alloxan diabetes
-
the enzyme is highly expressed in immune cells elicited to the mouse peritoneum during thioglycollate-induced peritonitis
-
the enzyme is upregulated in rheumatoid arthritis
-
the expression of isoform 11beta-HSD1 in the epidermis of atopic dermatitis lesions is higher than that in the epidermis of healthy controls