1.1.1.133: dTDP-4-dehydrorhamnose reductase

This is an abbreviated version!
For detailed information about dTDP-4-dehydrorhamnose reductase, go to the full flat file.

Reaction

Synonyms

4-ketoreductase, Agl14, bifunctional UDP-4-keto-6-deoxy-D-glucose epimerase/reductase, dTDP-4-dehydrorhamnose reductase, dTDP-4-keto-L-rhamnose reductase, dTDP-4-keto-rhamnose reductase, dTDP-4-ketorhamnose reductase, dTDP-6-deoxy-L-lyxo-4-hexulose reductase, dTDP-6-deoxy-L-mannose dehydrogenase, dTDP-L-rhamnose synthetase, gacA, RfbD, RmlD, TDP-4-keto-rhamnose reductase, TDP-4-ketorhamnose reductase, thymidine diphosphate-4-dehydrorhamnose reductase, thymidine diphosphate-6-deoxy-L-talose, thymidine diphospho-4-ketorhamnose reductase, UGER

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.133 dTDP-4-dehydrorhamnose reductase

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Results	in table
38989	AA Sequence
2	Application
1	CAS Registry Number
9	Cloned(Commentary)
19	Cofactor
4	Crystallization (Commentary)
2	General Information
1	General Stability
4	IC50 Value
7	Inhibitors
6	KM Value [mM]
4	Metals/Ions
16	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
19	Organism
8	Pathway
17	PDB ID
4	pH Optimum
1	pH Range
1	pH Stability
7	Purification (Commentary)
2	Reaction
3	Reaction Type
19	Reference
4	Source Tissue
2	Specific Activity [micromol/min/mg]
3	Storage Stability
23	Substrates and Products (Substrate)
5	Subunits
30	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
2	Turnover Number [1/s]

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General Information on EC 1.1.1.133 - dTDP-4-dehydrorhamnose reductase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug target

Bacillus anthracis

A0A6L7H7R4

the dTDP-beta-L-rhamnose-biosynthetic pathway is absent in humans, which make them ideal targets for therapeutic development to combat pathogens (e.g. Bacillus anthracis, the causative agent of the deadly disease Anthrax)

762573

metabolism

Bacillus anthracis

A0A6L7H7R4

enzyme in the dTDP-beta-L-rhamnose-biosynthetic pathway

762573