1.1.1.122: D-threo-aldose 1-dehydrogenase
This is an abbreviated version!
For detailed information about D-threo-aldose 1-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.122
Reaction
Synonyms
(2S,3R)-aldose dehydrogenase, FDH, L-fucose (D-arabinose) dehydrogenase, L-fucose dehydrogenase, Sso1300
ECTree
1.1.1.122 D-threo-aldose 1-dehydrogenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.1.1.122 - D-threo-aldose 1-dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-deoxy-D-ribose + NAD+
? + NADH
Ovis aries aries
-
10% of the activity compared to L-fucose or D-arabinose
-
?
3-amino-3-deoxy-D-arabinose + NAD+
3-amino-3-deoxy-D-arabino-1,5-lactone + NADH
-
15% of the activity compared to L-fucose
-
?
3-amino-3-deoxy-D-arabinose + NAD+
3-amino-3-deoxy-D-arabino-1,5-lactone + NADH + H+
-
-
-
-
r
D-ribose + NAD+
? + NADH
-
8% of the activity compared to D-arabinose or L-xylose
-
?
L-galactose + NADP+
?
-
L-galactose is a poor substrate with 11% activity compared to L-fucose
-
-
?
L-glucose + NAD+
L-glucono-1,5-lactone + NADH
-
68% of the activity compared to D-arabinose or L-xylose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
irreversible because of spontaneous conversion to L-fuconic acid during incubation
-
ir
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
ir
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
Ovis aries aries
-
ordered bi-bi-reaction mechanism
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
Ovis aries aries
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
Ovis aries aries
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
i.e. L-fucose
-
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
i.e. L-fucose. The enzyme is specific for sugars with D-arabinose-type hydroxyl group stereo-configurations at C3 and C4. This configuration is shared among the hexoses L-fucose (6-deoxy-L-galactose) and L-galactose, and the pentose D-ribose. Although the highest activity is observed with L-fucose in combination with NAD+, the remaining sugars are oxidized at higher rates using NADP+
-
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
i.e. L-fucose. The enzyme is specific for sugars with D-arabinose-type hydroxyl group stereo-configurations at C3 and C4. This configuration is shared among the hexoses L-fucose (6-deoxy-L-galactose) and L-galactose, and the pentose D-ribose. Although the highest activity is observed with L-fucose in combination with NAD+, the remaining sugars are oxidized at higher rates using NADP+
-
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
i.e. L-fucose
-
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
73% of the activity compared to D-arabinose or L-xylose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
71% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
74.5% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
74.5% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
84% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
66% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
100% activity
-
?
D-arabinose + NADP+
D-arabinolactone + NADPH + H+
-
good substrate with 65% activity compared to L-fucose
-
-
?
D-arabinose + NADP+
D-arabinolactone + NADPH + H+
-
good substrate with 65% activity compared to L-fucose
-
-
?
D-galactose + NAD+
D-galactono-1,5-lactone + NADH + H+
-
-
-
-
r
D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
-
2.1% of the activity compared to L-fucose
-
?
D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
-
9% of the activity compared to D-arabinose or L-xylose
-
?
L-fucose + NADP+
L-fuconolactone + NADPH + H+
-
good substrate
-
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
57% of the activity compared to L-fucose
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
59.6% of the activity compared to L-fucose
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
59.6% of the activity compared to L-fucose
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
13% of the activity compared to L-fucose
-
?
L-xylose + NAD+
L-xylono-1,5-lactone + NADH
-
4% of the activity compared to L-fucose
-
?
additional information
?
-
-
no activity with D-glucose, D-fructose, D-galactose, L-arabinose, D-mannose, L-rhamnose, D-xylose, maltose, sucrose, and lactose
-
-
?
additional information
?
-
-
no activity with D-glucose, D-fructose, D-galactose, L-arabinose, D-mannose, L-rhamnose, D-xylose, maltose, sucrose, and lactose
-
-
?
