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Sequence of CLAT_HUMAN

EC Number:2.3.1.6

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
choline O-acetyltransferase
P28329
Homo sapiens
748
82536
Reaction
acetyl-CoA + choline = CoA + O-acetylcholine
Other sequences found for EC No. 2.3.1.6

General information:

Sequence
show sequence in fasta format
  0 MGLRTAKKRG LGGGGKWKRE EGGGTRGRRE VRPACFLQSG GRGDPGDVGG PAGNPGCSPH
 60 PRAATRPPPL PAHTPAHTPE WCGAASAEAA EPRRAGPHLC IPAPGLTKTP ILEKVPRKMA
120 AKTPSSEESG LPKLPVPPLQ QTLATYLQCM RHLVSEEQFR KSQAIVQQFG APGGLGETLQ
180 QKLLERQEKT ANWVSEYWLN DMYLNNRLAL PVNSSPAVIF ARQHFPGTDD QLRFAASLIS
240 GVLSYKALLD SHSIPTDCAK GQLSGQPLCM KQYYGLFSSY RLPGHTQDTL VAQNSSIMPE
300 PEHVIVACCN QFFVLDVVIN FRRLSEGDLF TQLRKIVKMA SNEDERLPPI GLLTSDGRSE
360 WAEARTVLVK DSTNRDSLDM IERCICLVCL DAPGGVELSD THRALQLLHG GGYSKNGANR
420 WYDKSLQFVV GRDGTCGVVC EHSPFDGIVL VQCTEHLLKH VTQSSRKLIR ADSVSELPAP
480 RRLRWKCSPE IQGHLASSAE KLQRIVKNLD FIVYKFDNYG KTFIKKQKCS PDAFIQVALQ
540 LAFYRLHRRL VPTYESASIR RFQEGRVDNI RSATPEALAF VRAVTDHKAA VPASEKLLLL
600 KDAIRAQTAY TVMAITGMAI DNHLLALREL ARAMCKELPE MFMDETYLMS NRFVLSTSQV
660 PTTTEMFCCY GPVVPNGYGA CYNPQPETIL FCISSFHSCK ETSSSKFAKA VEESLIDMRD
720 LCSLLPPTES KPLATKEKAT RPSQGHQP
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
402194
Oda Y.,Nakanishi I.,Deguchi T.
A complementary DNA for human choline acetyltransferase induces two forms of enzyme with different molecular weights in cultured cells.
Brain Res. Mol. Brain Res.
16
287-294
1992
402195
Ohno K.,Tsujino A.,Brengman J.M.,Harper C.M.,Bajzer Z.,Udd B.,Beyring R.,Robb S.,Kirkham F.J.,Engel A.G.
Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans.
Proc. Natl. Acad. Sci. U.S.A.
98
2017-2022
2001
402196
Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.
The DNA sequence and comparative analysis of human chromosome 10.
Nature
429
375-381
2004
402198
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
402199
Lorenzi M.V.,Trinidad A.C.,Zhang R.,Strauss W.L.
Two mRNAs are transcribed from the human gene for choline acetyltransferase.
DNA Cell Biol.
11
593-603
1992
402200
Toussaint J.L.,Geoffroy V.,Schmitt M.,Werner A.,Garnier J.-M.,Simoni P.,Kempf J.
Human choline acetyltransferase (CHAT): partial gene sequence and potential control regions.
Genomics
12
412-416
1992
402201
Hersh L.B.,Takane K.,Gylys K.,Moomaw C.,Slaughter C.
Conservation of amino acid sequences between human and porcine choline acetyltransferase.
J. Neurochem.
51
1843-1845
1988
402202
Cervini R.,Rocchi M.,DiDonato S.,Finocchiaro G.
Isolation and sub-chromosomal localization of a DNA fragment of the human choline acetyltransferase gene.
Neurosci. Lett.
132
191-194
1991
402203
Kim A.-R.,Rylett R.J.,Shilton B.H.
Substrate binding and catalytic mechanism of human choline acetyltransferase.
Biochemistry
45
14621-14631
2006
402204
Kraner S.,Laufenberg I.,Strassburg H.M.,Sieb J.P.,Steinlein O.K.
Congenital myasthenic syndrome with episodic apnea in patients homozygous for a CHAT missense mutation.
Arch. Neurol.
60
761-763
2003