Sequence of NDH_MYCTU
EC Number:1.6.5.9
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
NADH:quinone reductase (non-electrogenic)
P95160
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
463
49619
Reaction
NADH + H+ + a quinone = NAD+ + a quinol
Other sequences found for EC No. 1.6.5.9
General information:
Sequence
0 MSPQQEPTAQ PPRRHRVVII GSGFGGLNAA KKLKRADVDI KLIARTTHHL FQPLLYQVAT
60 GIISEGEIAP PTRVVLRKQR NVQVLLGNVT HIDLAGQCVV SELLGHTYQT PYDSLIVAAG
120 AGQSYFGNDH FAEFAPGMKS IDDALELRGR ILSAFEQAER SSDPERRAKL LTFTVVGAGP
180 TGVEMAGQIA ELAEHTLKGA FRHIDSTKAR VILLDAAPAV LPPMGAKLGQ RAAARLQKLG
240 VEIQLGAMVT DVDRNGITVK DSDGTVRRIE SACKVWSAGV SASRLGRDLA EQSRVELDRA
300 GRVQVLPDLS IPGYPNVFVV GDMAAVEGVP GVAQGAIQGA KYVASTIKAE LAGANPAERE
360 PFQYFDKGSM ATVSRFSAVA KIGPVEFSGF IAWLIWLVLH LAYLIGFKTK ITTLLSWTVT
420 FLSTRRGQLT ITDQQAFART RLEQLAELAA EAQGSAASAK VAS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
324153
Cole S.T.,Brosch R.,Parkhill J.,Garnier T.,Churcher C.M.,Harris D.E.,Gordon S.V.,Eiglmeier K.,Gas S.,Barry C.E. III,Tekaia F.,Badcock K.,Basham D.,Brown D.,Chillingworth T.,Connor R.,Davies R.M.,Devlin K.,Feltwell T.,Gentles S.,Hamlin N.,Holroyd S.,Hornsby T.,Jagels K.,Krogh A.,McLean J.,Moule S.,Murphy L.D.,Oliver S.,Osborne J.,Quail M.A.,Rajandream M.A.,Rogers J.,Rutter S.,Seeger K.,Skelton S.,Squares S.,Squares R.,Sulston J.E.,Taylor K.,Whitehead S.,Barrell B.G.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature
393
537-544
1998
324154
Weinstein E.A.,Yano T.,Li L.S.,Avarbock D.,Avarbock A.,Helm D.,McColm A.A.,Duncan K.,Lonsdale J.T.,Rubin H.
Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs.
Proc. Natl. Acad. Sci. U.S.A.
102
4548-4553
2005
324155
Kelkar D.S.,Kumar D.,Kumar P.,Balakrishnan L.,Muthusamy B.,Yadav A.K.,Shrivastava P.,Marimuthu A.,Anand S.,Sundaram H.,Kingsbury R.,Harsha H.C.,Nair B.,Prasad T.S.,Chauhan D.S.,Katoch K.,Katoch V.M.,Kumar P.,Chaerkady R.,Ramachandran S.,Dash D.,Pandey A.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol. Cell. Proteomics
10
0-0
2011
324156
Awasthy D.,Ambady A.,Narayana A.,Morayya S.,Sharma U.
Roles of the two type II NADH dehydrogenases in the survival of Mycobacterium tuberculosis in vitro.
Gene
550
110-116
2014
324157
Vilcheze C.,Weinrick B.,Leung L.W.,Jacobs W.R. Jr.
Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence.
Proc. Natl. Acad. Sci. U.S.A.
115
1599-1604
2018
324158
Murugesan D.,Ray P.C.,Bayliss T.,Prosser G.A.,Harrison J.R.,Green K.,Soares de Melo C.,Feng T.S.,Street L.J.,Chibale K.,Warner D.F.,Mizrahi V.,Epemolu O.,Scullion P.,Ellis L.,Riley J.,Shishikura Y.,Ferguson L.,Osuna-Cabello M.,Read K.D.,Green S.R.,Lamprecht D.A.,Finin P.M.,Steyn A.J.C.,Ioerger T.R.,Sacchettini J.,Rhee K.Y.,Arora K.,Barry C.E. III,Wyatt P.G.,Boshoff H.I.M.
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.
ACS Infect. Dis.
4
954-969
2018
