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Sequence of RENI_HUMAN

EC Number:3.4.23.15

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
renin
P00797
Homo sapiens
406
45057
Reaction
cleavage of Leu-/- bond in angiotensinogen to generate angiotensin I
Other sequences found for EC No. 3.4.23.15

General information:

Sequence
show sequence in fasta format
  0 MDGWRRMPRW GLLLLLWGSC TFGLPTDTTT FKRIFLKRMP SIRESLKERG VDMARLGPEW
 60 SQPMKRLTLG NTTSSVILTN YMDTQYYGEI GIGTPPQTFK VVFDTGSSNV WVPSSKCSRL
120 YTACVYHKLF DASDSSSYKH NGTELTLRYS TGTVSGFLSQ DIITVGGITV TQMFGEVTEM
180 PALPFMLAEF DGVVGMGFIE QAIGRVTPIF DNIISQGVLK EDVFSFYYNR DSENSQSLGG
240 QIVLGGSDPQ HYEGNFHYIN LIKTGVWQIQ MKGVSVGSST LLCEDGCLAL VDTGASYISG
300 STSSIEKLME ALGAKKRLFD YVVKCNEGPT LPDISFHLGG KEYTLTSADY VFQESYSSKK
360 LCTLAIHAMD IPPPTGPTWA LGATFIRKFY TEFDRRNNRI GFALAR
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1109877
Imai T.,Miyazaki H.,Hirose S.,Hori H.,Hayashi T.,Kageyama R.,Ohkubo H.,Nakanishi S.,Murakami K.
Cloning and sequence analysis of cDNA for human renin precursor.
Proc. Natl. Acad. Sci. U.S.A.
80
7405-7409
1983
1109878
Morris B.J.
New possibilities for intracellular renin and inactive renin now that the structure of the human renin gene has been elucidated.
Clin. Sci.
71
345-355
1986
1109879
Hardman J.A.,Hort Y.J.,Catanzaro D.F.,Tellam J.T.,Baxter J.D.,Morris B.J.,Shine J.
Primary structure of the human renin gene.
DNA
3
457-468
1984
1109883
Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence and biological annotation of human chromosome 1.
Nature
441
315-321
2006
1109884
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1109885
Soubrier F.,Panthier J.-J.,Corvol P.,Rougeon F.
Molecular cloning and nucleotide sequence of a human renin cDNA fragment.
Nucleic Acids Res.
11
7181-7190
1983
1109886
Fukamizu A.,Nishi K.,Nishimatsu S.,Miyazaki H.,Hirose S.,Murakami K.
Human renin gene of renin-secreting tumor.
Gene
49
139-145
1986
1109887
Burt D.W.,Nakamura N.,Kelley P.,Dzau V.J.
Identification of negative and positive regulatory elements in the human renin gene.
J. Biol. Chem.
264
7357-7362
1989
1109888
Soubrier F.,Panthier J.J.,Houot A.-M.,Rougeon F.,Corvol P.
Segmental homology between the promoter region of the human renin gene and the mouse ren1 and ren2 promoter regions.
Gene
41
85-92
1986
1109889
Ishizuka Y.,Shoda A.,Yoshida S.,Kawamura Y.,Haraguchi K.,Murakami K.
Isolation and characterization of recombinant human prorenin in Chinese hamster ovary cells.
J. Biochem.
109
30-35
1991
1109890
Nguyen G.,Delarue F.,Burckle C.,Bouzhir L.,Giller T.,Sraer J.-D.
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.
J. Clin. Invest.
109
1417-1427
2002
1109891
Sielecki A.R.,Hayakawa K.,Fujinaga M.,Murphy M.E.P.,Fraser M.,Muir A.K.,Carilli C.T.,Lewicki J.A.,Baxter J.D.,James M.N.G.
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5-A resolution.
Science
243
1346-1351
1989
1109892
Dhanaraj V.,Dealwis C.G.,Frazao C.,Badasso M.,Sibanda B.L.,Tickle I.J.,Cooper J.B.,Driessen H.P.C.,Newman M.,Aguilar C.,Wood S.P.,Blundell T.L.,Hobart P.M.,Geoghegan K.F.,Ammirati M.J.,Danley D.E.,O'Connor B.A.,Hoover D.J.
X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins.
Nature
357
466-472
1992
1109893
Zhou A.,Carrell R.W.,Murphy M.P.,Wei Z.,Yan Y.,Stanley P.L.,Stein P.E.,Broughton Pipkin F.,Read R.J.
A redox switch in angiotensinogen modulates angiotensin release.
Nature
468
108-111
2010
1109894
Gribouval O.,Gonzales M.,Neuhaus T.,Aziza J.,Bieth E.,Laurent N.,Bouton J.M.,Feuillet F.,Makni S.,Ben Amar H.,Laube G.,Delezoide A.-L.,Bouvier R.,Dijoud F.,Ollagnon-Roman E.,Roume J.,Joubert M.,Antignac C.,Gubler M.-C.
Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.
Nat. Genet.
37
964-968
2005
1109895
Zivna M.,Hulkova H.,Matignon M.,Hodanova K.,Vylet'al P.,Kalbacova M.,Baresova V.,Sikora J.,Blazkova H.,Zivny J.,Ivanek R.,Stranecky V.,Sovova J.,Claes K.,Lerut E.,Fryns J.P.,Hart P.S.,Hart T.C.,Adams J.N.,Pawtowski A.,Clemessy M.,Gasc J.M.,Guebler M.C.,Antignac C.,Elleder M.,Kapp K.,Grimbert P.,Bleyer A.J.,Kmoch S.
Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure.
Am. J. Hum. Genet.
85
204-213
2009