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Sequence of THAS_HUMAN

EC Number:5.3.99.5

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
thromboxane-A synthase
P24557
Homo sapiens
533
60518
Reaction
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
Other sequences found for EC No. 5.3.99.5

General information:

Sequence
show sequence in fasta format
  0 MEALGFLKLE VNGPMVTVAL SVALLALLKW YSTSAFSRLE KLGLRHPKPS PFIGNLTFFR
 60 QGFWESQMEL RKLYGPLCGY YLGRRMFIVI SEPDMIKQVL VENFSNFTNR MASGLEFKSV
120 ADSVLFLRDK RWEEVRGALM SAFSPEKLNE MVPLISQACD LLLAHLKRYA ESGDAFDIQR
180 CYCNYTTDVV ASVAFGTPVD SWQAPEDPFV KHCKRFFEFC IPRPILVLLL SFPSIMVPLA
240 RILPNKNRDE LNGFFNKLIR NVIALRDQQA AEERRRDFLQ MVLDARHSAS PMGVQDFDIV
300 RDVFSSTGCK PNPSRQHQPS PMARPLTVDE IVGQAFIFLI AGYEIITNTL SFATYLLATN
360 PDCQEKLLRE VDVFKEKHMA PEFCSLEEGL PYLDMVIAET LRMYPPAFRF TREAAQDCEV
420 LGQRIPAGAV LEMAVGALHH DPEHWPSPET FNPERFTAEA RQQHRPFTYL PFGAGPRSCL
480 GVRLGLLEVK LTLLHVLHKF RFQACPETQV PLQLESKSAL GPKNGVYIKI VSR
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1005601
Yokoyama C.,Miyata A.,Ihara H.,Ullrich V.,Tanabe T.
Molecular cloning of human platelet thromboxane A synthase.
Biochem. Biophys. Res. Commun.
178
1479-1484
1991
1005602
Ohashi K.,Ruan K.H.,Kulmacz R.J.,Wu K.K.,Wang L.-H.
Primary structure of human thromboxane synthase determined from the cDNA sequence.
J. Biol. Chem.
267
789-793
1992
1005603
Miyata A.,Yokoyama C.,Ihara H.,Bandoh S.,Takeda O.,Takahashi E.,Tanabe T.
Characterization of the human gene (TBXAS1) encoding thromboxane synthase.
Eur. J. Biochem.
224
273-279
1994
1005605
Chevalier D.,Lo-Guidice J.-M.,Sergent E.,Allorge D.,Debuysere H.,Ferrari N.,Libersa C.,Lhermitte M.,Broly F.
Identification of genetic variants in the human thromboxane synthase gene (CYP5A1).
Mutat. Res.
432
61-67
2001
1005606
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
1005607
Hillier L.W.,Fulton R.S.,Fulton L.A.,Graves T.A.,Pepin K.H.,Wagner-McPherson C.,Layman D.,Maas J.,Jaeger S.,Walker R.,Wylie K.,Sekhon M.,Becker M.C.,O'Laughlin M.D.,Schaller M.E.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Cordes M.,Du H.,Sun H.,Edwards J.,Bradshaw-Cordum H.,Ali J.,Andrews S.,Isak A.,Vanbrunt A.,Nguyen C.,Du F.,Lamar B.,Courtney L.,Kalicki J.,Ozersky P.,Bielicki L.,Scott K.,Holmes A.,Harkins R.,Harris A.,Strong C.M.,Hou S.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Leonard S.,Rohlfing T.,Rock S.M.,Tin-Wollam A.-M.,Abbott A.,Minx P.,Maupin R.,Strowmatt C.,Latreille P.,Miller N.,Johnson D.,Murray J.,Woessner J.P.,Wendl M.C.,Yang S.-P.,Schultz B.R.,Wallis J.W.,Spieth J.,Bieri T.A.,Nelson J.O.,Berkowicz N.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Bedell J.A.,Mardis E.R.,Clifton S.W.,Chissoe S.L.,Marra M.A.,Raymond C.,Haugen E.,Gillett W.,Zhou Y.,James R.,Phelps K.,Iadanoto S.,Bubb K.,Simms E.,Levy R.,Clendenning J.,Kaul R.,Kent W.J.,Furey T.S.,Baertsch R.A.,Brent M.R.,Keibler E.,Flicek P.,Bork P.,Suyama M.,Bailey J.A.,Portnoy M.E.,Torrents D.,Chinwalla A.T.,Gish W.R.,Eddy S.R.,McPherson J.D.,Olson M.V.,Eichler E.E.,Green E.D.,Waterston R.H.,Wilson R.K.
The DNA sequence of human chromosome 7.
Nature
424
157-164
2003
1005609
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1005610
Wang L.-H.,Oshashi K.,Wu K.K.
Isolation of partial complementary DNA encoding human thromboxane synthase.
Biochem. Biophys. Res. Commun.
177
286-291
1991
1005611
Nuesing R.,Schneider-Voss S.,Ullrich V.
Immunoaffinity purification of human thromboxane synthase.
Arch. Biochem. Biophys.
280
325-330
1990
1005613
Yokoyama C.,Miyata A.,Suzuki K.,Nishikawa Y.,Yoshimoto T.,Yamamoto S.,Nuesing R.,Ullrich V.,Tanabe T.
Expression of human thromboxane synthase using a baculovirus system.
FEBS Lett.
318
91-94
1993
1005614
Ruan K.H.,Wang L.-H.,Wu K.K.,Kulmacz R.J.
Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum.
J. Biol. Chem.
268
19483-19490
1993
1005615
Hsu P.Y.,Tsai A.L.,Kulmacz R.J.,Wang L.H.
Expression, purification, and spectroscopic characterization of human thromboxane synthase.
J. Biol. Chem.
274
762-769
1999
1005616
Mestel F.,Oetliker O.,Beck E.,Felix R.,Imbach P.,Wagner H.P.
Severe bleeding associated with defective thromboxane synthetase.
Lancet
1
157-157
1980
1005617
Hsu P.Y.,Tsai A.L.,Wang L.H.
Identification of thromboxane synthase amino acid residues involved in heme-propionate binding.
Arch. Biochem. Biophys.
383
119-127
2000
1005618
Wang L.H.,Tsai A.L.,Hsu P.Y.
Substrate binding is the rate-limiting step in thromboxane synthase catalysis.
J. Biol. Chem.
276
14737-14743
2001
1005619
Yeh H.C.,Tsai A.L.,Wang L.H.
Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases.
Arch. Biochem. Biophys.
461
159-168
2007
1005620
Matsunobu T.,Okuno T.,Yokoyama C.,Yokomizo T.
Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand.
J. Lipid Res.
54
2979-2987
2013
1005621
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
1005622
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
1005623
Cargill M.,Altshuler D.,Ireland J.,Sklar P.,Ardlie K.,Patil N.,Shaw N.,Lane C.R.,Lim E.P.,Kalyanaraman N.,Nemesh J.,Ziaugra L.,Friedland L.,Rolfe A.,Warrington J.,Lipshutz R.,Daley G.Q.,Lander E.S.
Characterization of single-nucleotide polymorphisms in coding regions of human genes.
Nat. Genet.
22
231-238
1999
1005625
Halushka M.K.,Fan J.-B.,Bentley K.,Hsie L.,Shen N.,Weder A.,Cooper R.,Lipshutz R.,Chakravarti A.
Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.
Nat. Genet.
22
239-247
1999
1005626
Saito S.,Iida A.,Sekine A.,Kawauchi S.,Higuchi S.,Ogawa C.,Nakamura Y.
Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.
J. Hum. Genet.
48
249-270
2003
1005627
Sjoeblom T.,Jones S.,Wood L.D.,Parsons D.W.,Lin J.,Barber T.D.,Mandelker D.,Leary R.J.,Ptak J.,Silliman N.,Szabo S.,Buckhaults P.,Farrell C.,Meeh P.,Markowitz S.D.,Willis J.,Dawson D.,Willson J.K.V.,Gazdar A.F.,Hartigan J.,Wu L.,Liu C.,Parmigiani G.,Park B.H.,Bachman K.E.,Papadopoulos N.,Vogelstein B.,Kinzler K.W.,Velculescu V.E.
The consensus coding sequences of human breast and colorectal cancers.
Science
314
268-274
2006
1005628
Genevieve D.,Proulle V.,Isidor B.,Bellais S.,Serre V.,Djouadi F.,Picard C.,Vignon-Savoye C.,Bader-Meunier B.,Blanche S.,de Vernejoul M.-C.,Legeai-Mallet L.,Fischer A.-M.,Le Merrer M.,Dreyfus M.,Gaussem P.,Munnich A.,Cormier-Daire V.
Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome).
Nat. Genet.
40
284-286
2008
1005629
Chen C.Y.,Poole E.M.,Ulrich C.M.,Kulmacz R.J.,Wang L.H.
Functional analysis of human thromboxane synthase polymorphic variants.
Pharmacogenet. Genomics
22
653-658
2012