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EC Number
pH Stability
pH Stability Maximum
Commentary
Reference
2.2.1.1
-999
-
thiamine diphosphate enhances pH-stability
485995
2.2.1.1
3
-
complete inactivation
720083
2.2.1.1
5
-
denaturation below
485995
2.2.1.1
5
-
thiamine diphosphate dissociates from holoenzyme
486002
,
486003
2.2.1.1
6
10
stable in the presence of cofactors
485995
2.2.1.1
6.5
-
below, unstable
486007
2.2.1.1
6.5
8.7
20°C, 20 min stable
486002
,
486003
2.2.1.1
9
-
high pH results in the formation of a native-like state that is only partially inactive. The apo-enzyme structure content also increases at pH 9 to converge on that of the holo-enzyme
720083
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