EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.22 | UDP-glucose 6-dehydrogenase |
chondrocyte |
articular |
-, 739967 |
1.1.1.22 | UDP-glucose 6-dehydrogenase |
chondrocyte |
articular chondrocyte |
690024 |
1.1.1.22 | UDP-glucose 6-dehydrogenase |
chondrocyte |
overexpression of c-Krox in articular chondrocytes depresses both UDPGD mRNA steady-state level and protein expression |
667414 |
1.13.11.33 | arachidonate 15-lipoxygenase |
chondrocyte |
express both 15-LOX-1 and -2 |
701977 |
1.13.11.34 | arachidonate 5-lipoxygenase |
chondrocyte |
osteoarthritic chondrocyte |
711045 |
1.13.11.5 | homogentisate 1,2-dioxygenase |
chondrocyte |
- |
712561 |
1.13.11.5 | homogentisate 1,2-dioxygenase |
chondrocyte |
primary culture, alkaptonuria chondrocytes show a 10% increase of the enzyme expression compared to normal ones |
725601 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
chondrocyte |
- |
657488 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
chondrocyte |
represents at least about 70% of the total enzyme activity, the type II enzyme represents the main enzyme form |
439243 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
chondrocyte |
osteoarthritic chondrocytes |
744188 |
1.14.11.67 | [histone H3]-trimethyl-L-lysine4 demethylase |
chondrocyte |
- |
744188 |
1.14.11.7 | procollagen-proline 3-dioxygenase |
chondrocyte |
- |
712433 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
chondrocyte |
- |
440226 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
chondrocyte |
iNOS is more frequently expressed in osteoarthritic than in normal chondrocytes, iNOS expression and activity in osteoarthritic chondrocytes is sub-maximal |
700490 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
chondrocyte |
nNOS is more frequently expressed in normal than in osteoarthritic chondrocytes |
700490 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
chondrocyte |
- |
728612 |
1.14.99.1 | prostaglandin-endoperoxide synthase |
chondrocyte |
- |
745945 |
1.4.3.13 | protein-lysine 6-oxidase |
chondrocyte |
- |
391742 |
1.5.3.16 | spermine oxidase |
chondrocyte |
- |
712558 |
2.1.1.357 | [histone H3]-lysine36 N-dimethyltransferase |
chondrocyte |
- |
755538 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
chondrocyte |
- |
758401 |
2.3.1.57 | diamine N-acetyltransferase |
chondrocyte |
- |
712558 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
chondrocyte |
malignant, swarm chondrosarcoma |
487845 |
2.3.3.8 | ATP citrate synthase |
chondrocyte |
normal and osteoarthritis human knee chondrocytes |
757200 |
2.4.1.132 | GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase |
chondrocyte |
- |
-, 736467 |
2.4.1.134 | galactosylxylosylprotein 3-beta-galactosyltransferase |
chondrocyte |
- |
702117 |
2.4.1.135 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase |
chondrocyte |
- |
721465 |
2.4.1.174 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase |
chondrocyte |
- |
723586, 736281 |
2.4.1.175 | glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase |
chondrocyte |
- |
702117, 723586, 736226 |
2.4.1.175 | glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase |
chondrocyte |
in nontumorous cartilages |
759331 |
2.4.1.224 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase |
chondrocyte |
articular chondrocyte |
759897 |
2.4.1.224 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase |
chondrocyte |
loss of one copy of either the EXT1 or EXT2 gene product compromises the perichondrial chondrocytes ability to differentiate normally and to survive in a differentiated state in vitro |
673272 |
2.4.1.225 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase |
chondrocyte |
articular chondrocyte |
759897 |
2.4.1.225 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase |
chondrocyte |
loss of one copy of either the EXT1 or EXT2 gene product compromises the perichondrial chondrocytes ability to differentiate normally and to survive in a differentiated state in vitro |
673272 |
2.4.1.226 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase |
chondrocyte |
in nontumorous cartilages |
759331 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
chondrocyte |
- |
722718 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
chondrocyte |
some positive staining in cells of both normal and arthritic joints as revealed by immunohistochemistry using rat monoclonal anti-murine NAMPT antibody |
694813 |
2.4.2.26 | protein xylosyltransferase |
chondrocyte |
- |
637622 |
2.4.2.26 | protein xylosyltransferase |
chondrocyte |
cell culture supernatant |
637615, 637616 |
2.4.2.26 | protein xylosyltransferase |
chondrocyte |
from heart sternal cartilage |
637615, 637616 |
2.7.1.137 | phosphatidylinositol 3-kinase |
chondrocyte |
- |
686034 |
2.7.10.1 | receptor protein-tyrosine kinase |
chondrocyte |
- |
490659 |
2.7.10.1 | receptor protein-tyrosine kinase |
chondrocyte |
fibroblast growth factor receptor |
660727 |
2.7.11.10 | IkappaB kinase |
chondrocyte |
- |
690668 |
2.7.11.12 | cGMP-dependent protein kinase |
chondrocyte |
- |
661575, 693352, 760323 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
chondrocyte |
- |
691978, 760806 |
2.7.11.24 | mitogen-activated protein kinase |
chondrocyte |
- |
665792 |
2.7.7.9 | UTP-glucose-1-phosphate uridylyltransferase |
chondrocyte |
hypertrophic and nonhypertrophic |
643756 |
2.8.2.17 | chondroitin 6-sulfotransferase |
chondrocyte |
embryo chondrocytes release enzyme into the cell culture medium |
645750, 645754, 645761 |
2.8.2.5 | chondroitin 4-sulfotransferase |
chondrocyte |
cell culture |
645750, 645751 |
2.8.2.5 | chondroitin 4-sulfotransferase |
chondrocyte |
embryo |
645750, 645751 |
2.8.2.5 | chondroitin 4-sulfotransferase |
chondrocyte |
extracellular, secretion to the medium |
645750 |
3.1.3.1 | alkaline phosphatase |
chondrocyte |
associated to memebranes, and in the inter-territorial region |
649496 |
3.1.3.1 | alkaline phosphatase |
chondrocyte |
hypertrophic |
650793 |
3.1.3.1 | alkaline phosphatase |
chondrocyte |
no activity in resting chondrocytes and the matrix of reserve zone |
652666 |
3.1.3.62 | multiple inositol-polyphosphate phosphatase |
chondrocyte |
fetal growth plate cartilage, mRNA expression |
646439 |
3.1.3.62 | multiple inositol-polyphosphate phosphatase |
chondrocyte |
MIPP expression pattern in developing chondrocytes |
646438 |
3.1.3.62 | multiple inositol-polyphosphate phosphatase |
chondrocyte |
nonsynchronous primary cultures of growth plate chondrocytes from rib cartilage, developmentally specific changes in MINPP expression |
646436 |
3.1.3.75 | phosphoethanolamine/phosphocholine phosphatase |
chondrocyte |
from growth plates of proximal tibiotarsi, 3X11A expression at high levels in differentiating growth plate chondrocytes, 3X11A expression is upregulated 5fold during chondrocyte terminal differentiation and its expression is approximately 100fold higher in hypertrophic chondrocytes than in non-chondrogenic tissues |
654794 |
3.1.4.1 | phosphodiesterase I |
chondrocyte |
- |
697620, 730170 |
3.1.4.1 | phosphodiesterase I |
chondrocyte |
high expression level |
707668 |
3.1.4.12 | sphingomyelin phosphodiesterase |
chondrocyte |
- |
690667 |
3.1.4.12 | sphingomyelin phosphodiesterase |
chondrocyte |
articular |
677878 |
3.1.4.4 | phospholipase D |
chondrocyte |
articular |
730316 |
3.1.4.50 | glycosylphosphatidylinositol phospholipase D |
chondrocyte |
localized predominantly to the extracellulat matrix of chondrocytes and to primary trabeculae of the skeleton |
664464 |
3.1.6.12 | N-acetylgalactosamine-4-sulfatase |
chondrocyte |
cultured embryo vertebral chondrocytes |
135547 |
3.1.8.1 | aryldialkylphosphatase |
chondrocyte |
PON1 |
692441 |
3.2.1.52 | beta-N-acetylhexosaminidase |
chondrocyte |
- |
708101 |
3.4.13.9 | Xaa-Pro dipeptidase |
chondrocyte |
- |
651194, 683868 |
3.4.15.1 | peptidyl-dipeptidase A |
chondrocyte |
- |
707920 |
3.4.17.12 | carboxypeptidase M |
chondrocyte |
- |
697395 |
3.4.21.107 | peptidase Do |
chondrocyte |
primary chondrocyte |
712536 |
3.4.21.112 | site-1 protease |
chondrocyte |
- |
717840 |
3.4.21.112 | site-1 protease |
chondrocyte |
S1P is abundantly expressed in the chondrocytes in the developing wild-type forelimb at all stages |
687906 |
3.4.21.41 | complement subcomponent C1r |
chondrocyte |
- |
81402 |
3.4.21.42 | complement subcomponent C1s |
chondrocyte |
- |
81402 |
3.4.21.79 | granzyme B |
chondrocyte |
- |
709759, 754761 |
3.4.21.B25 | PACE4 proprotein convertase |
chondrocyte |
hypertrophic chondrocyte |
731787 |
3.4.22.1 | cathepsin B |
chondrocyte |
- |
753138 |
3.4.22.38 | cathepsin K |
chondrocyte |
- |
-, 697066, 700549, 708450 |
3.4.22.53 | calpain-2 |
chondrocyte |
- |
687156 |
3.4.22.56 | caspase-3 |
chondrocyte |
- |
647598 |
3.4.22.56 | caspase-3 |
chondrocyte |
induction of apoptosis with mitomycin-c in presence or absence of general caspase inhibitor benzoyl-Val-Ala-Asp-fluoromethylketone. Benzoyl-Val-Ala-Asp-fluoromethylketone prevents mitomycin-c-induced cell death. In contrast, specific inhibition of enzyme or caspase-7 in presence of mitomycin-c induces necrotic-like or paraptotic-like morphological changes but does not prevent cell death |
669604 |
3.4.22.61 | caspase-8 |
chondrocyte |
ofloxacin induces apoptosis in microencapsulated juvenile rabbit chondrocytes by caspase-8-dependent mitochondrial pathway |
682905 |
3.4.22.B24 | calpain 4 |
chondrocyte |
- |
718110 |
3.4.24.11 | neprilysin |
chondrocyte |
from articular cartilage |
81631 |
3.4.24.17 | stromelysin 1 |
chondrocyte |
- |
709685 |
3.4.24.19 | procollagen C-endopeptidase |
chondrocyte |
- |
668838 |
3.4.24.22 | stromelysin 2 |
chondrocyte |
- |
707310 |
3.4.24.35 | gelatinase B |
chondrocyte |
- |
-, 700527, 733693 |
3.4.24.35 | gelatinase B |
chondrocyte |
articular chondrocyte of the late-stage osteoarthritis cartilage with surface fibrillation and chondrocyte clusters, not in healthy chondrocytes, overview |
683376 |
3.4.24.65 | macrophage elastase |
chondrocyte |
metalloproteinase 12 (MMP-12) is induced in chondrocytes during fetal development and malignant transformation |
754996 |
3.4.24.7 | interstitial collagenase |
chondrocyte |
- |
709685, 709913 |
3.4.24.82 | ADAMTS-4 endopeptidase |
chondrocyte |
- |
667360, 667400, 669206, 669244, 677881, 679302, 695404, 695608, 699350, 733229, 752659 |
3.4.24.82 | ADAMTS-4 endopeptidase |
chondrocyte |
articular chondrocyte |
678446 |
3.4.24.82 | ADAMTS-4 endopeptidase |
chondrocyte |
degradative chondrocytes express ADAMTS-4 |
701193 |
3.4.24.82 | ADAMTS-4 endopeptidase |
chondrocyte |
humans with osteoarthritis |
697932 |
3.4.24.B10 | ADAM12 endopeptidase |
chondrocyte |
- |
669565, 734620 |
3.4.24.B11 | ADAMTS1 endopeptidase |
chondrocyte |
humans with osteoarthritis |
697932 |
3.4.24.B12 | ADAMTS5 endopeptidase |
chondrocyte |
- |
677881, 679302, 679600, 680863, 695404, 720364, 733229 |