EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.1 | alcohol dehydrogenase |
aorta |
the activity of the class I ADH isoenzyme is significantly lower in the wall of aortic aneurysm than in healthy aorta |
697802 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
aorta |
- |
741244 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
aorta |
abdominal, expression level determination, especially in female aorta with mild atherosclerotic changes |
668413 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
aorta |
- |
701239 |
1.1.1.179 | D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) |
aorta |
- |
286124 |
1.1.1.21 | aldose reductase |
aorta |
- |
286239, 668380, 711762, 711859 |
1.1.1.21 | aldose reductase |
aorta |
vascular smooth muscle cells |
669468 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
aorta |
26% mRNA expression of Rdh5 compared to liver |
690797 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
aorta |
- |
701239 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
aorta |
transgenic mouse |
698045 |
1.11.1.6 | catalase |
aorta |
- |
655134 |
1.11.2.2 | myeloperoxidase |
aorta |
atherosclerotic aorta |
697307 |
1.13.11.33 | arachidonate 15-lipoxygenase |
aorta |
- |
-, 684349, 742845 |
1.13.11.34 | arachidonate 5-lipoxygenase |
aorta |
expression is not significantly different between diabetic and control rats. Activation of the 5-lipoxygenase previously reported in streptozotocin-induced diabetic rats can be explained by an augmented sensitivity to cysteinyl leukotrienes in the diabetic aorta |
660412 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
aorta |
- |
745084 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
aorta |
embryo |
439200 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
aorta |
rat abdominal aortas |
-, 745084 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
aorta |
expression only of LH2long |
659845 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
aorta |
of control and hyperglycemic mice |
697557 |
1.14.12.17 | nitric oxide dioxygenase |
aorta |
endothelial cells |
658747 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
aorta |
- |
745938 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
aorta |
thoracic, muscle |
685867 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
aorta |
- |
688237 |
1.15.1.1 | superoxide dismutase |
aorta |
- |
685864 |
1.17.3.2 | xanthine oxidase |
aorta |
- |
688155, 689994 |
1.17.3.2 | xanthine oxidase |
aorta |
lower enzyme activity compared to vena cava |
684354 |
1.17.3.2 | xanthine oxidase |
aorta |
smooth muscle cells |
688146 |
1.17.3.2 | xanthine oxidase |
aorta |
wall |
686890 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
aorta |
- |
711625 |
1.2.1.5 | aldehyde dehydrogenase [NAD(P)+] |
aorta |
- |
688446 |
1.2.1.94 | farnesal dehydrogenase |
aorta |
- |
717961 |
1.2.3.1 | aldehyde oxidase |
aorta |
- |
693075 |
1.4.3.13 | protein-lysine 6-oxidase |
aorta |
- |
391736, 391737, 391739, 391742, 655021, 659558, 675286, 684802, 695968, 699875, 713462, 724520 |
1.4.3.13 | protein-lysine 6-oxidase |
aorta |
co-localization of LOX and LOXL |
659751 |
1.4.3.13 | protein-lysine 6-oxidase |
aorta |
different spatial and temporal expression of LOX and LOXL1 during growth and aging, expression analysis of LOXL1 and LOX in the aorta during the development, growth, and aging of LOU rats, overview |
701156 |
1.4.3.13 | protein-lysine 6-oxidase |
aorta |
LOX, LOXL, LOXL3, low expression level of LOXL2 |
658189 |
1.4.3.21 | primary-amine oxidase |
aorta |
- |
687449, 688603 |
1.4.3.5 | pyridoxal 5'-phosphate synthase |
aorta |
1.2% of the activity in liver |
655483 |
1.5.1.34 | 6,7-dihydropteridine reductase |
aorta |
- |
741864 |
1.6.2.4 | NADPH-hemoprotein reductase |
aorta |
- |
-, 288616 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
aorta |
- |
685975, 711166, 711763, 713366 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
aorta |
abdominal aortic endothelial cells |
686418 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
aorta |
aortas of transgenic rats harboring the mouse renin transgene exhibit greater NADPH oxidase activity, reactive oxygen species levels, C-reactive protein, tumor necrosis factor-alpha expression, apoptosis, and wall thickness, which are significantly attenuated by in vivo treatment with angiotensin type 1 receptor blockade by valsartan or the superoxide dismutase/catalase mimetic tempol |
687049 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
aorta |
aortic ring |
684351 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
aorta |
aortic rings |
685982 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
aorta |
cultured aortic smooth muscle cell |
684269 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
aorta |
Exposure of mouse aortic rings to hypoxia/reoxygenation significantly increases vessel outgrowth, whereas pharmacological inhibition of NADPH oxidase or genetic deletion of the NADPH oxidase subunit, p47phox significantly suppresses these changes. Increases in myocardial serine-threonine kinase Akt and ERK1/2 activation and vascular endothelial growth factor expression are markedly blunted in the subunit p47phox-deficient mouse subjected to myocardial ischemia-reperfusion compared with the wild-type mouse |
684345 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
aorta |
hemin treatment increases hemin oxidase-1 expression and activity in aorta and kidney of apolipoprotein E-deficient mice and significantly reduces both NADPH oxidase activity and superoxide generation in situ. Effects are reversed by tin protoporphyrin-IX and are not associated with changes in isoforms Nox2 or Nox4 protein levels. Inhibition of NADPH oxidase activity by hemin in the aorta is mimicked by bilirubin in vitro |
687050 |
1.8.4.12 | peptide-methionine (R)-S-oxide reductase |
aorta |
- |
686598 |
1.8.4.2 | protein-disulfide reductase (glutathione) |
aorta |
- |
394828 |
1.8.5.8 | eukaryotic sulfide quinone oxidoreductase |
aorta |
- |
764408 |
2.1.1.6 | catechol O-methyltransferase |
aorta |
- |
686194 |
2.1.1.71 | phosphatidyl-N-methylethanolamine N-methyltransferase |
aorta |
- |
485560 |
2.3.1.149 | Platelet-activating factor acetyltransferase |
aorta |
immunohistochemistry shows PAF-AH expression in the intima and in the media of the aorta |
693520 |
2.3.1.26 | sterol O-acyltransferase |
aorta |
- |
486688, 486698, 486703 |
2.3.1.26 | sterol O-acyltransferase |
aorta |
41fold induction of activity after 60 days of cholesterol feeding |
486683 |
2.3.1.26 | sterol O-acyltransferase |
aorta |
atheroschlerotic tissue |
486688, 486703 |
2.3.1.26 | sterol O-acyltransferase |
aorta |
extremely low activity |
486704 |
2.4.1.131 | GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase |
aorta |
intimal layer |
638569 |
2.4.1.255 | protein O-GlcNAc transferase |
aorta |
- |
703977 |
2.4.1.255 | protein O-GlcNAc transferase |
aorta |
distribution of OGTase in the aorta is examined by immunofluorescence microscopy |
701898 |
2.4.1.87 | N-acetyllactosaminide 3-alpha-galactosyltransferase |
aorta |
- |
489479 |
2.4.3.9 | lactosylceramide alpha-2,3-sialyltransferase |
aorta |
atherosclerotic and normal aorta |
705676 |
2.4.3.9 | lactosylceramide alpha-2,3-sialyltransferase |
aorta |
atherosclerotic aortic intima |
658140 |
2.4.3.9 | lactosylceramide alpha-2,3-sialyltransferase |
aorta |
level of GM3 synthase in membrane-fractions isolated from the atherosclerotic intima are higher compared to those in non-dieased arterial tissue |
657703 |
2.5.1.57 | N-acylneuraminate-9-phosphate synthase |
aorta |
- |
637818 |
2.6.1.42 | branched-chain-amino-acid transaminase |
aorta |
endothelial cells |
640023 |
2.7.1.127 | inositol-trisphosphate 3-kinase |
aorta |
smooth muscle |
640742, 640743 |
2.7.1.52 | fucokinase |
aorta |
- |
641674, 661521, 703298 |
2.7.10.1 | receptor protein-tyrosine kinase |
aorta |
smooth muscle |
660727 |
2.7.10.2 | non-specific protein-tyrosine kinase |
aorta |
endothelial cells, PYK2 |
673110 |
2.7.11.10 | IkappaB kinase |
aorta |
- |
760461 |
2.7.11.12 | cGMP-dependent protein kinase |
aorta |
- |
662462, 674575, 704619, 721982, 722222 |
2.7.11.12 | cGMP-dependent protein kinase |
aorta |
aortic homogenate, neointima |
721982 |
2.7.11.12 | cGMP-dependent protein kinase |
aorta |
high expression of isozymes PKG-1alpha and PKG-1beta |
660671 |
2.7.11.12 | cGMP-dependent protein kinase |
aorta |
smooth muscle |
661575 |
2.7.11.13 | protein kinase C |
aorta |
- |
662054 |
2.7.11.16 | G-protein-coupled receptor kinase |
aorta |
- |
491168 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
aorta |
- |
491257, 491258, 640685, 671227 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
aorta |
smooth muscle |
640688 |
2.7.11.18 | myosin-light-chain kinase |
aorta |
- |
491268, 661664, 687732 |
2.7.11.18 | myosin-light-chain kinase |
aorta |
thoracic |
640625 |
2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
aorta |
- |
-, 644987, 693032, 704431 |
2.7.3.2 | creatine kinase |
aorta |
- |
642371 |
2.7.7.23 | UDP-N-acetylglucosamine diphosphorylase |
aorta |
- |
643065 |
2.7.7.30 | fucose-1-phosphate guanylyltransferase |
aorta |
- |
645224 |
2.7.8.15 | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase |
aorta |
- |
645351, 645353 |
2.7.8.27 | sphingomyelin synthase |
aorta |
- |
668729 |
2.7.8.27 | sphingomyelin synthase |
aorta |
high expression of SMS1 mRNA |
668729 |
2.8.1.2 | 3-mercaptopyruvate sulfurtransferase |
aorta |
3MST and cytosolic and mitochondrial cysteine aminotransferases are localized to endothelial cells of the thoracic aorta |
704359 |
2.8.2.15 | steroid sulfotransferase |
aorta |
aortic smooth muscle cell line CRL-1999 |
645740 |
2.8.2.4 | estrone sulfotransferase |
aorta |
female aortic smooth muscle cell line CRL-1999 cell |
645740 |
2.8.2.8 | [heparan sulfate]-glucosamine N-sulfotransferase |
aorta |
- |
-, 762448 |
3.1.1.13 | sterol esterase |
aorta |
- |
133849 |
3.1.1.34 | lipoprotein lipase |
aorta |
aortic endothelial cells |
665649 |
3.1.1.34 | lipoprotein lipase |
aorta |
highest expression is found in aorta |
690660 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
aorta |
atherogenic aorta |
693520 |
3.1.2.2 | palmitoyl-CoA hydrolase |
aorta |
- |
646158 |
3.1.2.20 | acyl-CoA hydrolase |
aorta |
- |
646158 |
3.1.3.1 | alkaline phosphatase |
aorta |
- |
693930 |