EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.188 | prostaglandin-F synthase |
amastigote |
- |
-, 761141 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
amastigote |
- |
-, 712042, 761074 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
amastigote |
- |
723129 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
amastigote |
axenic, high enzyme expression level |
671631 |
1.14.14.154 | sterol 14alpha-demethylase |
amastigote |
- |
701584, 705030, 744843 |
1.14.19.22 | acyl-lipid omega-6 desaturase (cytochrome b5) |
amastigote |
- |
675584 |
1.17.4.1 | ribonucleoside-diphosphate reductase |
amastigote |
- |
-, 687333 |
1.17.99.9 | heme a synthase |
amastigote |
the amount of mRNA is significantly lower compared with the other life stages |
759201 |
1.17.99.9 | heme a synthase |
amastigote |
the replicative life stages (epimastigotes and amastigotes) show higher TcCox15 levels than the infective and non-replicative stage (trypomastigotes). Two times higher level in epimastigotes than in amastigotes and five times higher level than in trypomastigotes |
-, 758753 |
1.3.1.34 | 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing] |
amastigote |
- |
759709 |
1.3.1.6 | fumarate reductase (NADH) |
amastigote |
- |
390843 |
1.3.1.72 | DELTA24-sterol reductase |
amastigote |
- |
-, 763824 |
1.3.1.9 | enoyl-[acyl-carrier-protein] reductase (NADH) |
amastigote |
- |
-, 765104 |
1.3.3.12 | L-galactonolactone oxidase |
amastigote |
- |
684985 |
1.3.3.4 | protoporphyrinogen oxidase |
amastigote |
- |
744529 |
1.5.1.33 | pteridine reductase |
amastigote |
- |
725762 |
1.6.2.4 | NADPH-hemoprotein reductase |
amastigote |
- |
688895 |
1.6.5.5 | NADPH:quinone reductase |
amastigote |
the enzyme is expressed throughout the Trypanosoma cruzi life cycle |
671365 |
1.8.1.12 | trypanothione-disulfide reductase |
amastigote |
- |
-, 697340, 724771, 725064 |
1.8.1.12 | trypanothione-disulfide reductase |
amastigote |
axenic, high expression level |
659589 |
2.1.1.41 | sterol 24-C-methyltransferase |
amastigote |
- |
706882 |
2.1.2.1 | glycine hydroxymethyltransferase |
amastigote |
- |
-, 676982 |
2.1.2.1 | glycine hydroxymethyltransferase |
amastigote |
preferentially expressed |
675874 |
2.1.2.10 | aminomethyltransferase |
amastigote |
- |
705607 |
2.3.1.255 | N-terminal amino-acid Nalpha-acetyltransferase NatA |
amastigote |
- |
-, 757472 |
2.3.1.256 | N-terminal methionine Nalpha-acetyltransferase NatC |
amastigote |
- |
-, 757472 |
2.3.1.97 | glycylpeptide N-tetradecanoyltransferase |
amastigote |
- |
659297 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
amastigote |
comparable activity in both promastigote and amastigote |
673490 |
2.5.1.10 | (2E,6E)-farnesyl diphosphate synthase |
amastigote |
- |
721830, 722094 |
2.5.1.47 | cysteine synthase |
amastigote |
intracellular |
-, 737462 |
2.5.1.58 | protein farnesyltransferase |
amastigote |
- |
637511 |
2.5.1.59 | protein geranylgeranyltransferase type I |
amastigote |
- |
688892 |
2.7.1.1 | hexokinase |
amastigote |
obtained from hamster lesion |
676293 |
2.7.1.35 | pyridoxal kinase |
amastigote |
- |
-, 759342 |
2.7.11.26 | tau-protein kinase |
amastigote |
- |
-, 704100 |
2.7.2.3 | phosphoglycerate kinase |
amastigote |
- |
738182 |
2.7.4.1 | ATP-polyphosphate phosphotransferase |
amastigote |
- |
-, 738411 |
2.7.4.33 | AMP-polyphosphate phosphotransferase |
amastigote |
- |
-, 738411 |
2.7.7.13 | mannose-1-phosphate guanylyltransferase |
amastigote |
- |
721301, 761134 |
2.7.7.7 | DNA-directed DNA polymerase |
amastigote |
Trypanosoma cruzi DNA polymerase beta is restricted to the antipodal sites of kDNA in replicative epimastigote and amastigote developmental stages, being strictly localized to kDNA antipodal sites between G1/S and early G2 phase in replicative epimastigotes |
723132 |
2.7.9.1 | pyruvate, phosphate dikinase |
amastigote |
- |
-, 738633 |
2.7.9.3 | selenide, water dikinase |
amastigote |
- |
661573 |
2.8.1.2 | 3-mercaptopyruvate sulfurtransferase |
amastigote |
- |
645569 |
3.1.1.32 | phospholipase A1 |
amastigote |
infective |
730354 |
3.1.1.32 | phospholipase A1 |
amastigote |
infective stage, high enzyme activity |
682242 |
3.1.26.4 | ribonuclease H |
amastigote |
- |
666288 |
3.1.3.48 | protein-tyrosine-phosphatase |
amastigote |
- |
-, 750734 |
3.1.3.48 | protein-tyrosine-phosphatase |
amastigote |
within the endocytic pathway |
664802 |
3.1.4.11 | phosphoinositide phospholipase C |
amastigote |
TcPI-PLC expression at high levels in the epimastigote and amastigote stages |
652082 |
3.2.1.14 | chitinase |
amastigote |
- |
679117 |
3.2.1.26 | beta-fructofuranosidase |
amastigote |
expressed to a higher extent in promastigotes than in amastigotes |
750234 |
3.2.2.1 | purine nucleosidase |
amastigote |
- |
326372, 326374, 326388 |
3.4.15.5 | Peptidyl-dipeptidase Dcp |
amastigote |
- |
670188 |
3.4.17.19 | Carboxypeptidase Taq |
amastigote |
- |
684959 |
3.4.21.83 | Oligopeptidase B |
amastigote |
- |
755071 |
3.4.22.51 | cruzipain |
amastigote |
- |
638886 |
3.4.22.B5 | CPB protease |
amastigote |
- |
-, 669711, 732753, 752915, 754984 |
3.4.22.B5 | CPB protease |
amastigote |
activity in amastigotes is some 20 times greater than that in the promastigote form |
647699 |
3.4.22.B5 | CPB protease |
amastigote |
isolated from infected mice, expression of CPB3-CPB18 |
668770 |
3.4.22.B6 | cathepsin B-like protease |
amastigote |
expression in virulence |
664706 |
3.4.24.36 | leishmanolysin |
amastigote |
- |
-, 31229, 718253, 718304 |
3.4.24.36 | leishmanolysin |
amastigote |
axenic amastigotes from Leishmania mexicana pifanoi grown under macrophage-free conditions |
31226 |
3.4.24.36 | leishmanolysin |
amastigote |
enzymes from promastigotes and amastigotes are not identical but immunologically related |
-, 31226 |
3.4.24.36 | leishmanolysin |
amastigote |
expresses the genes MSPL and MSPC |
-, 683857 |
3.4.24.36 | leishmanolysin |
amastigote |
isolated from the spleens of infected hamsters and transformed to promastigotes at 26°C |
-, 683418 |
3.5.1.89 | N-acetylglucosaminylphosphatidylinositol deacetylase |
amastigote |
- |
-, 755748 |
3.5.3.1 | arginase |
amastigote |
intracellular |
754290 |
3.5.99.6 | glucosamine-6-phosphate deaminase |
amastigote |
- |
720877 |
3.6.1.11 | exopolyphosphatase |
amastigote |
- |
687628 |
3.6.1.5 | apyrase |
amastigote |
- |
-, 756679 |
3.6.1.5 | apyrase |
amastigote |
12fold increase in activity compared to promastigote |
668527 |
4.1.1.17 | ornithine decarboxylase |
amastigote |
- |
747987 |
4.1.1.17 | ornithine decarboxylase |
amastigote |
from livers and spleens of BALB/c mice |
-, 698257 |
4.2.1.11 | phosphopyruvate hydratase |
amastigote |
- |
714875 |
4.2.1.22 | cystathionine beta-synthase |
amastigote |
intracellular amastigote |
746764 |
4.2.99.18 | DNA-(apurinic or apyrimidinic site) lyase |
amastigote |
enzyme is present and active in the two replicative parasite forms, epimastigotes and amastigotes, as well as in the nonreplicative, infective trypomastigotes |
-, 730104 |
4.2.99.B1 | DNA 5'-deoxyribose phosphate lyase |
amastigote |
strain MCAN/ES/89/IPZ229/1/89, the enzyme activity varies with the life cycle of Leishmania infantum, being maximal in the intracellular amastigote phase |
692012 |
4.6.1.2 | guanylate cyclase |
amastigote |
- |
-, 680181 |
5.2.1.8 | peptidylprolyl isomerase |
amastigote |
- |
714320 |
5.3.1.6 | ribose-5-phosphate isomerase |
amastigote |
- |
-, 678047 |
5.6.1.7 | chaperonin ATPase |
amastigote |
CPN10 is a heat shock protein and shows increased intracellular concentration at an elevated temperature and in axenically cultivated amastigotes |
670103 |
5.6.1.7 | chaperonin ATPase |
amastigote |
GroES homologue |
670103 |
6.1.1.1 | tyrosine-tRNA ligase |
amastigote |
- |
-, 745348 |
6.3.1.2 | glutamine synthetase |
amastigote |
- |
-, 745708 |
6.3.1.2 | glutamine synthetase |
amastigote |
expression levels are maximal in the amastigote stage of the life cycle, when amino acids are preferably consumed, and NH4+ production is predictable |
-, 743570 |
6.3.1.9 | trypanothione synthase |
amastigote |
LiTRYS is constitutively expressed in Leishmania infantum axenic amastigotes |
-, 744964 |
6.3.4.5 | argininosuccinate synthase |
amastigote |
more abundantly expressed in amastigotes than in promastigotes |
728544 |
7.4.2.1 | ABC-type polar-amino-acid transporter |
amastigote |
- |
-, 749046 |
7.6.2.2 | ABC-type xenobiotic transporter |
amastigote |
- |
-, 734833 |