EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
Hep-G2 cell |
- |
740536 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
Hep-G2 cell |
induction by peroxisome-proliferator-activated receptor alpha ligands |
684725 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
Hep-G2 cell |
- |
656356 |
1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) |
Hep-G2 cell |
- |
761589 |
1.1.1.26 | glyoxylate reductase |
Hep-G2 cell |
- |
739241 |
1.1.1.27 | L-lactate dehydrogenase |
Hep-G2 cell |
- |
747163 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
Hep-G2 cell |
- |
675595 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
Hep-G2 cell |
HepG2 cells which lack 3-ketohydroxysteroid reductase/DELTA5-4ketosteroid isomerase mRNA expression, but express AKR1C1-AKR1C3 are able to convert 17beta-hydroxy-5alpha-androstan-3-one to 3beta-androstanediol and 3alpha-androstanediol |
656200 |
1.1.1.29 | glycerate dehydrogenase |
Hep-G2 cell |
- |
737421, 739241 |
1.1.1.34 | hydroxymethylglutaryl-CoA reductase (NADPH) |
Hep-G2 cell |
- |
684808 |
1.1.1.41 | isocitrate dehydrogenase (NAD+) |
Hep-G2 cell |
- |
741458 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
Hep-G2 cell |
- |
685421 |
1.1.1.44 | phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) |
Hep-G2 cell |
- |
741456 |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
Hep-G2 cell |
hepatoma cell |
656787 |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
Hep-G2 cell |
hepatoma cell, expresses isozymes AKR1C1-AKR1C3 |
656200 |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
Hep-G2 cell |
isozyme AKR1C2 |
656651 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
Hep-G2 cell |
- |
670108 |
1.1.1.79 | glyoxylate reductase (NADP+) |
Hep-G2 cell |
- |
739241 |
1.1.1.88 | hydroxymethylglutaryl-CoA reductase |
Hep-G2 cell |
- |
761340 |
1.10.5.1 | ribosyldihydronicotinamide dehydrogenase (quinone) |
Hep-G2 cell |
- |
725669, 763913 |
1.11.1.24 | thioredoxin-dependent peroxiredoxin |
Hep-G2 cell |
0.0033 mg Prx I per mg of soluble protein Prx I, 0.0013 mg Prx II per mg of soluble protein, 0.0005 mg Prx III per mg of soluble protein, 0.0005 mg Prx V per mg of soluble protein and 0.0017 mg Prx VI per mg of soluble protein |
655756 |
1.11.1.27 | glutathione-dependent peroxiredoxin |
Hep-G2 cell |
- |
763922 |
1.11.1.6 | catalase |
Hep-G2 cell |
overexpression of hepatitis C virus non-structural proteins increases catalase activity |
675325 |
1.11.1.9 | glutathione peroxidase |
Hep-G2 cell |
- |
677215, 742715 |
1.13.11.11 | tryptophan 2,3-dioxygenase |
Hep-G2 cell |
- |
743821, 764108 |
1.13.11.20 | cysteine dioxygenase |
Hep-G2 cell |
hepatoblastoma cells, enzyme expression is up-regulated under hypertonic conditions |
657832 |
1.13.11.27 | 4-hydroxyphenylpyruvate dioxygenase |
Hep-G2 cell |
- |
726347 |
1.13.11.34 | arachidonate 5-lipoxygenase |
Hep-G2 cell |
- |
741862 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
Hep-G2 cell |
- |
712906 |
1.14.11.27 | [histone H3]-dimethyl-L-lysine36 demethylase |
Hep-G2 cell |
- |
726260 |
1.14.11.29 | hypoxia-inducible factor-proline dioxygenase |
Hep-G2 cell |
- |
725596, 744664 |
1.14.11.30 | hypoxia-inducible factor-asparagine dioxygenase |
Hep-G2 cell |
- |
725596 |
1.14.11.54 | mRNA N1-methyladenine demethylase |
Hep-G2 cell |
- |
765483 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
Hep-G2 cell |
- |
752646, 753825 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
Hep-G2 cell |
- |
758422 |
1.14.11.67 | [histone H3]-trimethyl-L-lysine4 demethylase |
Hep-G2 cell |
- |
757659 |
1.14.13.148 | trimethylamine monooxygenase |
Hep-G2 cell |
- |
718455 |
1.14.13.8 | flavin-containing monooxygenase |
Hep-G2 cell |
- |
718455, 743293 |
1.14.14.1 | unspecific monooxygenase |
Hep-G2 cell |
CYP1A1 and CYP1A2 |
706841 |
1.14.14.154 | sterol 14alpha-demethylase |
Hep-G2 cell |
- |
685534 |
1.14.14.17 | squalene monooxygenase |
Hep-G2 cell |
- |
697143, 735329 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
Hep-G2 cell |
- |
684502, 686555, 688105 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
Hep-G2 cell |
Hep-G2 cell line C34 |
685997 |
1.14.14.23 | cholesterol 7alpha-monooxygenase |
Hep-G2 cell |
- |
671675, 671693, 673456, 689381, 697591, 698159, 712675, 723941, 736169 |
1.14.14.23 | cholesterol 7alpha-monooxygenase |
Hep-G2 cell |
different catechins, (-)-epicatechin gallate, (-)-epigallocatechin-3-gallate, (-)-epigallocatechin and (-)-epicatechin, up-regulates the CYP7A1 mRNA level by 5.5-, 4.2-, 2.9- and 1.9-fold, respectively, compared with the control |
685861 |
1.14.14.23 | cholesterol 7alpha-monooxygenase |
Hep-G2 cell |
HepG2 cell transformed with a cyp7alpha-reporter gene (promoter fragment fused to firefly luciferase) |
698408 |
1.14.14.23 | cholesterol 7alpha-monooxygenase |
Hep-G2 cell |
importance of histone deacetylases in the feedback regulation of CYP7A1 transcription |
687007 |
1.14.14.29 | 25/26-hydroxycholesterol 7alpha-hydroxylase |
Hep-G2 cell |
- |
705397 |
1.14.14.78 | phylloquinone omega-hydroxylase |
Hep-G2 cell |
- |
729122 |
1.14.14.94 | leukotriene-B4 20-monooxygenase |
Hep-G2 cell |
constitutively expressed in hepatoma cell line Hep-G2 |
390074 |
1.14.15.15 | cholestanetriol 26-monooxygenase |
Hep-G2 cell |
- |
702407, 702408 |
1.14.16.1 | phenylalanine 4-monooxygenase |
Hep-G2 cell |
- |
673309, 697830 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
Hep-G2 cell |
- |
688230, 695468, 695567, 696671, 696680, 696683, 697777, 697824, 699187, 701346, 727140, 744487, 746433 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
Hep-G2 cell |
HepG2 |
437665 |
1.14.19.17 | sphingolipid 4-desaturase |
Hep-G2 cell |
- |
744061 |
1.14.19.44 | acyl-CoA (8-3)-desaturase |
Hep-G2 cell |
- |
734434 |
1.14.99.29 | deoxyhypusine monooxygenase |
Hep-G2 cell |
- |
715197 |
1.14.99.38 | cholesterol 25-monooxygenase |
Hep-G2 cell |
- |
727109 |
1.14.99.66 | [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase |
Hep-G2 cell |
- |
752646 |
1.17.4.4 | vitamin-K-epoxide reductase (warfarin-sensitive) |
Hep-G2 cell |
- |
725987 |
1.18.1.6 | adrenodoxin-NADP+ reductase |
Hep-G2 cell |
HepG2/4TO-NOS, HepG2 cell line stably overexpressing endothelial nitric oxide synthase, NOS-3 |
744400 |
1.2.1.12 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) |
Hep-G2 cell |
- |
743173 |
1.2.1.13 | glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) |
Hep-G2 cell |
- |
672334 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
Hep-G2 cell |
- |
694110 |
1.2.1.84 | alcohol-forming fatty acyl-CoA reductase |
Hep-G2 cell |
- |
741434 |
1.2.3.1 | aldehyde oxidase |
Hep-G2 cell |
- |
692569 |
1.2.4.1 | pyruvate dehydrogenase (acetyl-transferring) |
Hep-G2 cell |
- |
700236 |
1.21.99.3 | thyroxine 5-deiodinase |
Hep-G2 cell |
isozyme Dio1 |
718384 |
1.21.99.4 | thyroxine 5'-deiodinase |
Hep-G2 cell |
- |
744792, 746225 |
1.21.99.4 | thyroxine 5'-deiodinase |
Hep-G2 cell |
isozyme Dio1 |
718384 |
1.3.1.21 | 7-dehydrocholesterol reductase |
Hep-G2 cell |
- |
654830, 740913 |
1.3.1.24 | biliverdin reductase |
Hep-G2 cell |
- |
698944, 701305, 711795 |
1.3.1.3 | DELTA4-3-oxosteroid 5beta-reductase |
Hep-G2 cell |
- |
763613 |
1.3.1.6 | fumarate reductase (NADH) |
Hep-G2 cell |
hepatocellular carcinoma cells |
713389 |
1.3.1.6 | fumarate reductase (NADH) |
Hep-G2 cell |
under hypoxic-hypoglycemic conditions, NADH-fumarate reductase activity increases, whereas NADH-oxidase activity decreases |
725318 |
1.3.1.70 | DELTA14-sterol reductase |
Hep-G2 cell |
- |
711302 |
1.3.1.72 | DELTA24-sterol reductase |
Hep-G2 cell |
- |
288497, 712405, 724442, 746181 |
1.3.1.72 | DELTA24-sterol reductase |
Hep-G2 cell |
hepatoma cell line HepG2 |
288497 |
1.3.1.93 | very-long-chain enoyl-CoA reductase |
Hep-G2 cell |
- |
745307 |
1.3.3.4 | protoporphyrinogen oxidase |
Hep-G2 cell |
- |
686939 |
1.3.8.9 | very-long-chain acyl-CoA dehydrogenase |
Hep-G2 cell |
- |
763263 |
1.4.3.1 | D-aspartate oxidase |
Hep-G2 cell |
- |
711325 |
1.4.3.13 | protein-lysine 6-oxidase |
Hep-G2 cell |
- |
684931 |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
Hep-G2 cell |
- |
392350 |
1.5.3.16 | spermine oxidase |
Hep-G2 cell |
- |
765802 |
1.5.3.17 | non-specific polyamine oxidase |
Hep-G2 cell |
- |
764224 |
1.6.2.2 | cytochrome-b5 reductase |
Hep-G2 cell |
- |
742526 |
1.6.2.4 | NADPH-hemoprotein reductase |
Hep-G2 cell |
- |
711717 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
Hep-G2 cell |
- |
684771, 686848 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
Hep-G2 cell |
transfection of isoform Nox3-specific siRNA abrogates H2O2 production and inhibitis exclusively the second phase of p42/44 MAPK phosphorylation and Sp1 DNA binding thus preventing upregulation of VEGF-A mRNA expression |
673469 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
Hep-G2 cell |
- |
684502 |
1.8.1.7 | glutathione-disulfide reductase |
Hep-G2 cell |
- |
677215, 690147 |
1.8.1.9 | thioredoxin-disulfide reductase |
Hep-G2 cell |
- |
685557, 687225, 742010 |
1.8.3.1 | sulfite oxidase |
Hep-G2 cell |
- |
741495 |
2.1.1.1 | nicotinamide N-methyltransferase |
Hep-G2 cell |
NNMT expression increased on stimulation of the cells with interleukin 6, NNMT promoter activity dependent on the activation of Stat3 |
687897 |
2.1.1.100 | protein-S-isoprenylcysteine O-methyltransferase |
Hep-G2 cell |
- |
733780 |
2.1.1.13 | methionine synthase |
Hep-G2 cell |
expression of both active 140 kDa form and the inactive truncated 124 kDa isoform |
756088 |
2.1.1.137 | arsenite methyltransferase |
Hep-G2 cell |
- |
718748, 733451, 735309, 755943 |
2.1.1.137 | arsenite methyltransferase |
Hep-G2 cell |
in a stable clonal HepG2/A cell line, AS3MT mRNA and protein levels are reduced by 83 and 88%, respectively. The capacity to methylate inorganic arsenic decreases by 70% |
673066 |
2.1.1.137 | arsenite methyltransferase |
Hep-G2 cell |
mRNA is detected after 35 or 45 cycles of amplification |
659168 |