EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
3.1.3.16 | protein-serine/threonine phosphatase |
aorta |
smooth muscle |
134605 |
3.1.3.4 | phosphatidate phosphatase |
aorta |
- |
665805 |
3.1.3.53 | [myosin-light-chain] phosphatase |
aorta |
- |
697357, 704517 |
3.1.3.53 | [myosin-light-chain] phosphatase |
aorta |
and large capacitance vessels, predominantly expression of 3-exon-out/leucine-zipper positive MYPT 1 isoform |
663585 |
3.1.3.53 | [myosin-light-chain] phosphatase |
aorta |
embryonic and adult, smooth muscle, throughout development, exclusive expression of the splice-in myosin-targeting subunit isoform |
646360 |
3.1.3.53 | [myosin-light-chain] phosphatase |
aorta |
expression of leucine-zipper positive isoform of MYPT 1 predominantes in healthy animal |
664610 |
3.1.3.53 | [myosin-light-chain] phosphatase |
aorta |
fetal, same MLCP activities in normal and pulmonary hypertensive fetal sheep |
646359 |
3.1.3.53 | [myosin-light-chain] phosphatase |
aorta |
fragments of the 110 kDa subunit |
646358 |
3.1.4.1 | phosphodiesterase I |
aorta |
arteries from hypertensive rats, vascular PDE1A, PDE1B, PDE1C, and PDE5 isoforms |
-, 715153 |
3.1.4.11 | phosphoinositide phospholipase C |
aorta |
PLC delta3 and delta4 |
649088 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
aorta |
- |
679248 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
aorta |
PDE1 |
670145 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
aorta |
PDE10 |
670145 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
aorta |
PDE11 |
670145 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
aorta |
PDE2 |
670145 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
aorta |
PDE3 |
670145 |
3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase |
aorta |
- |
711920, 711923 |
3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase |
aorta |
PDE5 |
670145 |
3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase |
aorta |
PDE6 |
670145 |
3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase |
aorta |
PDE9 |
670145 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
aorta |
- |
685021, 750336 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
aorta |
PDE4 |
670145 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
aorta |
PDE7 |
670145 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
aorta |
PDE8 |
670145 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
aorta |
weak activity |
685021 |
3.1.6.2 | steryl-sulfatase |
aorta |
abdominal, STS expression levels are higher in the vascular smooth muscle cells obtained from female aortas with mild atherosclerotic changes than in those with severe atherosclerotic changes in male aortas regardless of atherosclerotic changes |
645740 |
3.1.6.2 | steryl-sulfatase |
aorta |
adult |
645797 |
3.2.1.18 | exo-alpha-sialidase |
aorta |
aortic smooth muscle |
695452 |
3.3.2.10 | soluble epoxide hydrolase |
aorta |
- |
707303, 708238, 709564, 710821 |
3.3.2.10 | soluble epoxide hydrolase |
aorta |
aortic endothelial cell, treatment with angiotensin II results in increased expression of soluble epoxide hydrolase at both the mRNA and protein level |
684014 |
3.3.2.10 | soluble epoxide hydrolase |
aorta |
aortic intima of both spontaneously hypertensive rats and rats infused with angiotensin II exhibits an elevated level of soluble epoxide hydrolase |
684014 |
3.3.2.6 | leukotriene-A4 hydrolase |
aorta |
aortic lesion |
684001 |
3.3.2.7 | hepoxilin-epoxide hydrolase |
aorta |
- |
647027 |
3.4.11.2 | membrane alanyl aminopeptidase |
aorta |
endothelial cell |
664320, 664501 |
3.4.13.18 | cytosol nonspecific dipeptidase |
aorta |
normal and from patients with aortic aneurysms |
137197 |
3.4.13.9 | Xaa-Pro dipeptidase |
aorta |
enzyme activity is increased in aortic dilatation compared to controls |
710614 |
3.4.14.2 | dipeptidyl-peptidase II |
aorta |
- |
651779 |
3.4.15.1 | peptidyl-dipeptidase A |
aorta |
- |
670113, 699781, 707783, 709124, 709149, 709653, 731569 |
3.4.15.1 | peptidyl-dipeptidase A |
aorta |
the direct antioxidative and anti-inflammatory effects of peroxisome proliferator-activated receptors ligands are associated with the inhibition of angiotensin converting enzyme expression in streptozotocin-induced diabetic rat aorta |
679664 |
3.4.16.2 | lysosomal Pro-Xaa carboxypeptidase |
aorta |
aortic aneurysm and normal aorta |
36275 |
3.4.17.23 | angiotensin-converting enzyme 2 |
aorta |
- |
762703 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
aorta |
vascular smooth muscle cells. UCH-L1 is up-regulated in injured arteries |
707391 |
3.4.21.37 | leukocyte elastase |
aorta |
aortic endothelial cells |
707071 |
3.4.21.37 | leukocyte elastase |
aorta |
aortic smooth muscle cells |
707071 |
3.4.21.39 | chymase |
aorta |
- |
699756 |
3.4.21.B26 | proprotein convertase 5 |
aorta |
- |
718009 |
3.4.21.B26 | proprotein convertase 5 |
aorta |
PC5A dominates |
675967 |
3.4.21.B5 | mast cell protease 5 |
aorta |
- |
699756 |
3.4.22.15 | cathepsin L |
aorta |
increased level of cathepsin L in atherosclerotic lesions compared with healthy aortas |
695435 |
3.4.22.27 | cathepsin S |
aorta |
smooth muscle cells |
667140 |
3.4.22.34 | Legumain |
aorta |
lesions at the aortic sinus and in injured carotid arteries of Apolipoprotein E deficient mice, mRNA expression increases with development of atherosclerosis in the aorta |
683113 |
3.4.22.38 | cathepsin K |
aorta |
in the macrophage-rich regions of atherosclerotic plaques |
708148 |
3.4.22.43 | cathepsin V |
aorta |
expression in aorta valve, control valves and stenotic valves analyzed |
683107 |
3.4.22.52 | calpain-1 |
aorta |
- |
708018 |
3.4.22.53 | calpain-2 |
aorta |
- |
708151 |
3.4.22.53 | calpain-2 |
aorta |
relatively high m-calpain expression levels in the inferior arch |
708018 |
3.4.22.B29 | calpain 9 |
aorta |
- |
664555 |
3.4.23.5 | cathepsin D |
aorta |
- |
36921 |
3.4.24.11 | neprilysin |
aorta |
tissue NEP activity and its protein and mRNA expression are lower in the late phase of the septic shock compared to the early phase of the shock and the control |
670860 |
3.4.24.14 | procollagen N-endopeptidase |
aorta |
- |
754590 |
3.4.24.15 | thimet oligopeptidase |
aorta |
aortic endothelial cell culture. Enzyme is sensitive to Gialpha2/3 inhibition. Under cyclic strain conditions, level of secreted enzyme increases 2.6fold |
667354 |
3.4.24.24 | gelatinase A |
aorta |
- |
754999 |
3.4.24.34 | neutrophil collagenase |
aorta |
matrix metalloproteinase-8 is increased at the site of abdominal aortic aneurysm rupture |
683357 |
3.4.24.34 | neutrophil collagenase |
aorta |
MMP-8 is localized to mesenchymal cells within the adventitia of the aortic wall |
668115 |
3.4.24.35 | gelatinase B |
aorta |
- |
697149, 699878 |
3.4.24.71 | endothelin-converting enzyme 1 |
aorta |
- |
683318 |
3.4.24.71 | endothelin-converting enzyme 1 |
aorta |
determination of enzyme expression by immunohistochemical analysis on atherosclerotic and nonatherosclerotic vascular tissue using a combination of ECE-1 isoform-specific antibodies, distinct expression patterns for ECE-1a and ECE-1c, overview |
683440 |
3.4.24.71 | endothelin-converting enzyme 1 |
aorta |
increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse |
-, 699415 |
3.4.24.80 | membrane-type matrix metalloproteinase-1 |
aorta |
aortic fibroblasts |
754508 |
3.4.24.81 | ADAM10 endopeptidase |
aorta |
- |
755575 |
3.4.24.82 | ADAMTS-4 endopeptidase |
aorta |
- |
755457 |
3.4.24.82 | ADAMTS-4 endopeptidase |
aorta |
low expression in non-atherosclerotic aorta |
677894 |
3.4.24.86 | ADAM 17 endopeptidase |
aorta |
- |
753291 |
3.4.24.86 | ADAM 17 endopeptidase |
aorta |
atherosclerotic lesions of apolipoprotein E-deficient mice |
667364 |
3.4.24.86 | ADAM 17 endopeptidase |
aorta |
intraluminal thrombus of human abdominal aortic aneurysm |
755575 |
3.4.24.86 | ADAM 17 endopeptidase |
aorta |
metalloproteases ADAM-9, ADAM-15, and ADAM-17 are upregulated in advanced human atherosclerotic lesions in samples from carotid, abdominal aortic, and femoral territories compared to samples from internal thoracic artery free of atherosclerotic plaques. ADAM-9, ADAM-15, and ADAM-17-expressing cells colocalize with CD68-positive cells of monocytic origin in the atherosclerotic plaques |
710868 |
3.4.24.B11 | ADAMTS1 endopeptidase |
aorta |
- |
755146 |
3.4.24.B12 | ADAMTS5 endopeptidase |
aorta |
- |
734180 |
3.4.24.B4 | matrix metalloproteinase-13 |
aorta |
healthy and elastase-perfused aortas. Increased MMP-13 in experimental abdominal aortic aneurysms in males compared with females, while there are no differences in aortic diameter, collagen, and MMP-13 levels in baseline males versus females, MMP-13 expression analysis, overview |
713523 |
3.4.24.B9 | ADAM9 endopeptidase |
aorta |
- |
710868 |
3.5.3.1 | arginase |
aorta |
- |
688758 |
3.5.3.1 | arginase |
aorta |
intact aorta |
670422 |
3.5.3.18 | dimethylargininase |
aorta |
- |
288970, 668120, 695485, 698209 |
3.5.4.16 | GTP cyclohydrolase I |
aorta |
- |
698049, 698205, 698211 |
3.5.4.9 | methenyltetrahydrofolate cyclohydrolase |
aorta |
- |
757773 |
3.6.1.13 | ADP-ribose diphosphatase |
aorta |
- |
209946 |
3.6.1.5 | apyrase |
aorta |
- |
210132, 210162 |
3.6.1.5 | apyrase |
aorta |
aortic endothelial cells |
210150 |
3.6.1.5 | apyrase |
aorta |
intima and media layers |
210168 |
3.6.1.5 | apyrase |
aorta |
smooth muscle cells |
210167 |
3.6.1.6 | nucleoside diphosphate phosphatase |
aorta |
- |
-, 719196 |
4.1.1.17 | ornithine decarboxylase |
aorta |
- |
695461 |
4.1.1.19 | arginine decarboxylase |
aorta |
highest activity of all tissues tested |
656583 |
4.1.1.22 | histidine decarboxylase |
aorta |
- |
665184 |
4.2.1.92 | hydroperoxide dehydratase |
aorta |
- |
684349 |
4.4.1.1 | cystathionine gamma-lyase |
aorta |
- |
690352, 692207, 695134, 707582, 746708 |
4.4.1.5 | lactoylglutathione lyase |
aorta |
- |
37413, 729179 |
4.4.1.5 | lactoylglutathione lyase |
aorta |
aortic sinus derived from apolipoprotein-E-knockout mouse on a high-fat diet for 6 months, enzyme expression is restricted to a subset of cells |
729179 |
4.6.1.1 | adenylate cyclase |
aorta |
- |
690360 |
4.6.1.2 | guanylate cyclase |
aorta |
- |
691542, 691656, 693256, 693826 |