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EC Number	Expression	Commentary	Reference
2.7.7.86	down	knockdown of Sp1 and CREB by siRNA causes 70-80% and 60-70% decrease of protein levels	760853
2.7.7.86	up	DNA from either invading microbes or self-origin triggers the enzymatic activity of cGAS	761723
2.7.7.86	up	transcription factors Sp1 and CREB regulate the transcription of the cGAS gene. Overexpression of Sp1 and CREB enhances the protein levels of cGAS by 2 and 2.5folds	760853

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Release 2023.1 (January 2023)