EC Number   |
Expression |
Reference |
|---|
    2.1.1.45 | down |
decreased mRNA expression after treatment with sodium butyrate or suberoylanilide hydroxamic acid |
705451 |
| 2.1.1.45 | down |
there is an approximately 2fold inverse relationship between thymidylate synthase expression and response to 5-fluoruracil |
702996 |
| 2.1.1.45 | down |
thymidylate synthase antisense oligodeoxynucleotide (ODN) 491 decreases thymidylate protein levels in HeLa cells with a concomitant increase in sensitivity to thymidylate synthase-targeting chemotherapeutics. In MCF-7 cells, ODN491 treatment is less effective at reducing thymidylate synthase mRNA and does not reduce thymidylate synthase protein, nor does it enhance sensitivity to thymidylate synthase-targeting or other chemotherapeutics. Treatment with either ODN 83 or ODN 491 reduces 6-fluoro-dUMP binding in HeLa cells by 59% and 62%, respectively, compared with control |
703391 |
| 2.1.1.45 | more |
DHFR activity in lysates of Escherichia coli expressing Tsf-TbDHFR-TS is about 6fold more active than those expressing His6-TbDHFR-TS. In addition, thymidylate synthase activity, which has proved elusive with the His6-protein, is detectable. Stabilization of the TS activity with dUMP, without affect on DHFR stability. No stabilisation observed with CH2THF and other pyrimidine nucleotides, including the uracil-containing ribonucleotides and deoxyribonucleotides, and the thymidine-containing deoxyribonucleotides, overview |
-, 743569 |
| 2.1.1.45 | up |
the expression of thymidylate synthase is increased by about 6fold when embryos are treated with 0.001 mM 5-fluorouracil and there is a greater than 10fold increase in the enzyme protein level after treatment with 0.0004 mM ZD1694 |
720809 |
| 2.1.1.45 | up |
thymidylate synthase mRNA levels of large-cell lung carcinoma cells are comparable of those of squamous cell carcinoma cells, but significantly higher than those of adenocarcinoma cells |
703257 |
