EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
   3.4.24.18 | brush border membrane |
- |
GO:0031526 AmiGO QuickGO |
-, 733066, 733288, 734296 |
| 3.4.24.18 | brush border membrane |
brush-border membranes of proximal tubules and intestines |
GO:0031526 AmiGO QuickGO |
-, 733064 |
| 3.4.24.18 | cell surface |
- |
GO:0009986 AmiGO QuickGO |
650462, 652104 |
| 3.4.24.18 | extracellular |
- |
- |
650462, 669250, 752474, 753321, 753345, 754028 |
| 3.4.24.18 | extracellular |
meprin alpha is constitutively shed by furin during the secretory pathway and secreted into extracellular space. Meprin alpha tends to oligomerize to huge complexes ring and chain like structures up to the mega Dalton range, which makes it the largest extracellular protease |
- |
734610 |
| 3.4.24.18 | extracellular |
shedded meprin A |
- |
-, 733064 |
| 3.4.24.18 | extracellular |
the enzyme is secreted |
- |
754593, 754965 |
| 3.4.24.18 | membrane |
- |
GO:0016020 AmiGO QuickGO |
-, 31018, 31020, 31022, 31025, 31027, 31029, 31031 |
| 3.4.24.18 | membrane |
ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A |
GO:0016020 AmiGO QuickGO |
734259 |
| 3.4.24.18 | membrane |
apical membrane of intestinal epithelial cells |
GO:0016020 AmiGO QuickGO |
-, 31021 |
