EC Number   |
Inhibitors |
Structure |
|---|
    2.2.1.9 | 4-[ethoxy(hydroxy)phosphoryl]-4-oxobutanoic acid |
inhibitor shows no significant inhibition of Mycobacterium tuberculosis growth in vitro under aerobic and hypoxic conditions |
   |
| 2.2.1.9 | 4-[hydroxy(methoxy)phosphoryl]-4-oxobutanoic acid |
competitive with respect to 2-oxoglutarate, uncompetitive with respect to (+)-5-(carboxymethoxy)-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid. Compound is proposed to bind to the active site and react with thiamine diphosphate but not proceed forward to products by cleavage of the C-P bond |
|
| 2.2.1.9 | 4-[hydroxy(methoxy)phosphoryl]-4-oxobutanoic acid |
inhibitor shows no significant inhibition of Mycobacterium tuberculosis growth in vitro under aerobic and hypoxic conditions |
|
| 2.2.1.9 | dihydroxy-2-naphthoic acid |
the potent inhibitor binds to domain II of the enzyme and inhibits its activity |
|
| 2.2.1.9 | methyl succinylphosphonate |
dead-end inhibitor |
|
