1.14.15.18 calcidiol 1-monooxygenase AOK-B50 cell - 698881 1.14.15.18 calcidiol 1-monooxygenase AOK-B50 cell parathyroid hormone increases CYP1alpha mRNA and protein in a time-dependent manner. H2O2 inhibits parathyroid hormone-stimulated CYP1alpha protein levels and 1,25(OH)2D production in a dose dependent manner. The catalytic activity of the CYP1alpha protein may be reduced by free radical damage in CYP27B1 cells 688676