2.1.1.111 anthranilate N-methyltransferase acridone alkaloid biosynthesis 2.3.1.159 acridone synthase acridone alkaloid biosynthesis 4.1.3.27 anthranilate synthase acridone alkaloid biosynthesis 6.2.1.32 anthranilate-CoA ligase Acridone alkaloid biosynthesis