Ontology Explorer - Search Results

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the activity of the class I ADH isoenzyme is significantly lower in the wall of aortic aneurysm than in healthy aorta
isoenzyme AA-ADH and BB-ADH most abundant in
females show 70% higher hepatic alcohol dehydrogenase activity and display 60% lower voluntary ethanol intake than males. Following ethanol administration (1 g/kg ip), females generate a transient blood acetaldehyde increase with levels that are 2.5fold greater than in males. Castration of males leads to an increase alcohol dehydrogenase activity the appearance of an acetaldehyde burst a reduction of voluntary ethanol intake comparable with that of females
the activities of total alcohol dehydrogenase, aldehyde dehydrogenase and class I alcohol dehydrogenase isoenzyme between cancer liver tissues and healthy hepatocytes might be a factor in ethanol metabolism disorders which can intensify carcinogenesis
the total alcohol dehydrogenase activity is significantly higher in cancer tissues than in healthy liver
the activities of total alcohol dehydrogenase, aldehyde dehydrogenase and class I alcohol dehydrogenase isoenzyme between cancer liver tissues and healthy hepatocytes might be a factor in ethanol metabolism disorders which can intensify carcinogenesis
total activity of alcohol dehydrogenase is not significantly different in cancer and normal cells. The differences between enzymes of drinkers and nondrinkers in both cancer and healthy tissue are not significant
the class III enzyme contributes by far the bulk of the total alcohol dehydrogenase activity
activity increases during the prepubertal development
isoenzyme TT-ADH is only found in testis
ADH3 plays an important role in systemic ethanol metabolism at higher levels of blood ethanol through activation by cytoplasmic solution hydrophobicity
among all tested classes of ADH isoenzymes, only class I has higher activity in serum of patients with breast cancer in stage IV. The total ADH activity is not significantly higher in patients with breast cancer than in healthy controls. The changes in activity, especially in class I ADH, appear to be caused by isoenzymes being released from the organ damaged by metastatic disease
the total ADH activity is significantly higher (44%) among patients with cancer than healthy ones. The activity of class I ADH isoenzymes is elevated only in the serum of patients with metastatic liver cancer. This increase of activity seems to be caused by the enzyme released from liver cancer cells and primary tumors originating in other organs
isozyme ADH4, the total alcohol dehydrogenase activity is significantly higher in cancer tissues than in healthy esophagus
the total alcohol dehydrogenase activity is significantly higher in cancer tissues than in healthy colorectum
stomach mucosa, mue-alcohol dehydrogenase
isozymes ADH5 and ADH4, the total alcohol dehydrogenase activity is significantly higher in cancer tissues than in healthy stomach
adhA transcription is induced by ethanol or n-propanol, adhA transcription is subject to glucose catabolite repression. Accordingly, both induction of AdhA activity and ethanol utilization are detected only after depletion of glucose
highest ethanol consumption rate in cultures grown on 0.79% w/v ethanol
during the biological aging of sherry wines, where Saccharomyces bayanus has to grow on ethanol owing to the absence of glucose, this isoenzyme plays a prominent role by converting the ethanol into acetaldehyde and producing NADH in the process. Overexpression of the gene ADH2 (from Saccharomyces cerevisiae) during alcoholic fermentation has no effect on the proteomic profile or the net production of some metabolites associated with glycolysis and alcoholic fermentation such as ethanol, acetaldehyde, and glycerol. However, it affects indirectly glucose and ammonium uptakes, cell growth, and intracellular redox potential, which lead to an altered metabolome
significantly expressed in ethanol medium; significantly expressed in ethanol medium
significantly expressed in ethanol medium; significantly expressed in ethanol medium
highest ethanol consumption rate in cultures grown on 0.79% w/v ethanol
peel and flesh, alcohol dehydrogenase is independent of ethylene modulation
upregulated during ripening, the enzyme plays a specific role in the regulation of aroma biosynthesis in melon fruit
the changes in the carbon metabolism-associated proteins reflect altered patterns of carbon flux in response to changes in ADH activity in transformed plant leaves
expression of Adh2 in the root apical meristem
expression of Adh2 in the root apical meristem
expression levels of L-xylulose reductase and its mRNA in the T lymphoma cells are markedly enhanced after the exposure to 9,10-phenanthrenequinone, and the induction is completely abolished by the ROS scavengers. L-Xylulose reductase is upregulated in the earlier step of the apoptosis and deteriorates the apoptotic signaling through the generation of ROS by the redox cycling of 9,10-phenanthrenequinone
from caput, corpus, and cauda, activity in descending order
Zellweger syndrome cell lines GM0228 and GM4340 and normal control cells
embryonic stem cells are critically dependent on the amino acid threonine, and threonine catabolism via the TDH enzyme is important to the growth and metabolic state of mouse embryonic stem cells
the mouse embryo expresses RDH1 as early as 7.0 days post-coitus, and expression is especially intense within the neural tube, gut, and neural crest at embryo day 10.5
mRNA for RoDH-4 is abundant in adult liver, where it is translated into RoDH-4 protein. Significant amounts of RoDH-4 message is detected in fetal liver
RDH8 localizes to photoreceptor outer segments
the highest level of RDH12 expression is in the retina where it is localised to the inner segments and cell bodies of rod and cone photoreceptors
epidermal keratinocytes, gene is expressed predominantly in the differentiating spinous layers
retinal dehydrogenase 2 is significantly elevated in psoriatic skin
significant amounts of RoDH-4 message is detected in fetal lung
cells grown on various sugars, D-fucose and D-glucose are effective inducers of D-aldohexose dehydrogenase, D-galactose induces only slightly, L-arabinose is no inducer
cells grown on various sugars, D-fucose and D-glucose are effective inducers of D-aldohexose dehydrogenase, D-galactose induces only slightly, L-arabinose is no inducer
inducible enzyme synthesis by growth in 2-deoxy-D-gluconate containing medium
inducible enzyme synthesis by growth in alginate-containing medium
inducible by growing in L-threonate-containing medium
stage 2, highest activity in salt stressed fruit bodies
sorbitol dehydrogenase is active throughout development
expression is higher at the young and mature stage than at other stages
flesh and vascular tissue; flesh and vascular tissue
isoform Sdh1, specific for kernel and endosperm. Maximaml expression at both mRNA and enzyme activity level during early kernel development
enzyme activity is higher in seed than in cortex per mg and fresh weight. Isoforms SDH1 and SDH3 are expressed in both seed and cortex tissue, isoform SDH2 expression is limited to cortex
expression in mature leaf is higher than in young and folded leaf
vascular tissue and mesophyll tissue of young and old leaves; vascular tissue and mesophyll tissue of young and old leaves
activity is higher than in cortex per mg and fresh weight, and contributes significantly to whole fruit activity during weeks 2-5 after bloom. Isoforms SDH1 and SDH3 are expressed in both seed and cortex tissue. Isoforms SDH6 and SDH9 are expressed in seed tissues only
isoform Sdh1, specific for kernel and endosperm
similar enzyme also named sorbitol-6-phosphate dehydrogenase from Eriobotrya japonica
expression of mRNA, no detection of protein or its catalytic activity
similar enzyme also named sorbitol-6-phosphate dehydrogenase from Eriobotrya japonica
expression of mRNA, no detection of protein or its catalytic activity
high level of expression at 30 days after full blooming, expression decreases at 38 days after full blooming and then is maintained at a constant level
55000 Da form of enzyme, level increases with preterm premature rupture of membrane
in preterm chorion, levles of 15-hydroxyprostaglandin dehydrogenase protein and activity are lower when compared to term, and are further reduced with the presence of infection. Preterm premature rapture of membranes and subclinical inflammation do not affect the levels of 29000 Da 15-hydroxyprostaglandin dehydrogenase protein in the fetal membranes
PGDH protein is concentrated in the parietal yolk sac membrane (PYS) lining the placental surface and in placental blood vessels
invasiveapocrine carcinoma cells correspond to a distinct molecular subtype of breast carcinomas characterized by the expression of 15-prostaglandin dehydrogenase alone or in combination with a novel form of acyl-CoA synthetase medium-chain family member 1, 15-prostaglandin dehydrogenase is not expressed by other breast cancer types
both 15-hydroxyprostaglandin dehydrogenase mRNA and protein levels are significantly higher in kidney cortex than in papilla. Enzyme is mainly localized to the tubular epithelial cells in kidney cortex and outer medulla
expression of the enzyme and the estrogen receptor is correlated
androgen-sensitive cancer cells LNCaP and hormone-independent PC3 cells, enzyme expression is induced by steroids
intense immunofluorescent staining for 15-hydroxyprostaglandin dehydrogenase in macula densa and glomerulus of cyclooxygenase-2 knock-out mice
intense immunofluorescent staining for 15-hydroxyprostaglandin dehydrogenase in macula densa and glomerulus of cyclooxygenase-2 knock-out mice
intense immunofluorescent staining for 15-hydroxyprostaglandin dehydrogenase in macula densa and glomerulus of cyclooxygenase-2 knock-out mice
enzyme is mainly localized to the tubular epithelial cells in kidney cortex and outer medulla
macula densa cell line, significantly lower enzyme levels than in a proximal tubule cell line. Treatment with an inhibitor of cyclooxygenase-2 increases enzyme level
non-small cell lung carcinoma cell line A549, expression of 15-PGDH is induced by dexamethason, prednisolone, betamethasone and triamcinolone
up-regulation of cyclooxygenase-2 expression by pro-inflammatory cytokines is accompanied by down-regluation of 15-hydroxyprostaglandin dehydrogenase expression. Over-expression of cyclooxygenase-2 but not -1 also attenuates 15-hydroxyprostaglandin dehydrogenase expression. Similarly, overexpression of 15-hydroxyprostaglandin dehydrogenase inhibits interleukin 1beta-induced cyclooxygenase-2 expression and results in apoptosis. The levels of 15-hydroxyprostaglandin dehydrogenase expression in transfected cells correlate positively with those of mesenchymal markers, and negatively with those of epithelial markers
the enzyme is expressed mainly in the glandular epithelium, enzyme activity during the oestrous cycle and early pregnancy, overview
15-hydroxyprostaglandin dehydrogenase is expressed mainly in keratinocytes and melanocytes
in hair follicle, 15-hydroxyprostaglandin dehydrogenase is expressed mainly in keratinocytes and melanocytes
in hair follicle, 15-hydroxyprostaglandin dehydrogenase is expressed mainly in keratinocytes and melanocytes
; loss of 15-hydroxyprostaglandin expression in 65% of lung cancers. Enzyme acts as a tumor suppressor in lung cancer
NSCLC cell, much lower expression of 15-hydroxyprostaglandin dehydrogenase in all NSCLC histologic groups compared with healthy lung cell. Treatment with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib increases the expression of the enzyme in a subset of NSCLC lines
reduced expression of 15-PGDH occurrs in tumor cells and is paralleled by decreased 15-PGDH activity in tumors; the amount of 15-PGDH is frequently decreased in NSCLC cells compared with adjacent normal lung
PGDH messenger RNA (mRNA) abundance decreases significantly in the visceral yolk sac membrane and the amnion throughout the last third of pregnancy
highly reduced enzyme expression in colon cancers, distribution of enzyme expression within the tissue in situ, overview
highly reduced enzyme expression in colon cancers, distribution of enzyme expression within the tissue in situ, overview
distribution of enzyme expression within the tissue in situ, overview
distribution of enzyme expression within the tissue in situ, overview
abdominal, expression level determination, especially in female aorta with mild atherosclerotic changes
in amnion epithelium immunoreactive 3betaHSD is found from first to third trimester and term
in syncytiotrophoblast, cytotrophoblast and intermediate trophoblast immunoreactive 3betaHSD is found from first to third trimester and term
subtegumentary areas of the neck and immature proglottids
subtegumentary areas of the neck and immature proglottids
subtegumentary areas of the neck and immature proglottids
HSD3B2 and CYB5A are immonolocalized in normal human adrenal glands. Their co-expression is demonstrated in the cortical cells located at the border between the zona fasciculata and zona reticularis in normal human adrenal
expression of hepatic but not testicular 3beta-hydroxysteroid dehydrogenase shows a negative relationship with the level of backfat androsterone and is accompanied by a reduced rate of the hepatic androsterone clearance. Low expression of enzyme protein in the liver of high androsterone pigs is accompanied by a reduced level of enzyme mRNA
induction by peroxisome-proliferator-activated receptor alpha ligands
isoform 3beta-hydroxysteroid dehydrogenase type 2
expression of hepatic but not testicular 3beta-hydroxysteroid dehydrogenase shows a negative relationship with the level of backfat androsterone
at early and mid pregnancy up to 71 days, 3beta-hydroxysteroid dehydrogenase protein is observed in large luteal cells, while on day 71, the enzyme is present exclusively in small luteal cells. Enzyme mRNA is detected in all investigated samples isolated at different stages of pregnancy
weak expression of 3beta-hydroxysteroid dehydrogenase in newly formed corpora lutea, which gradually increases followed by decrease on day 20. In vascularised apical region of young corpora lutea, luteal cells with more intensive immunostaining predominate. Distribution of 3beta-hydroxysteroid dehydrogenase and androgen receptor differ within various generations of corpora lutea
twenty-four hours after bilateral contusion of the medial prefrontal cortex, similar levels of 3beta-hydroxysteroid dehydrogenase mRNA expression are observed in males and pseudopregnant females in the non-injured group, with a significant decrease in the 3beta-hydroxysteroid dehydrogenase mRNA expression in the contusion site within the frontal cortex in both males and pseudopregnant females. In all other regions analyzed, 3beta-hydroxysteroid dehydrogenase mRNA expression is not affected by traumatic brain injury and there is no difference between males and pseudopregnant females
HSDB1 transcript abundance in the endometrium and myometrium remain at the same level during the examined days of pregnancy. After luteolysis both endometrial and myometrial HSD3B1 expression wane
HSDB1 transcript abundance in the endometrium and myometrium remain at the same level during the examined days of pregnancy. After luteolysis both endometrial and myometrial HSD3B1 expression wane
of normotensive and hypertensive rats, the latter are hyperthrophied and fibrotic and have structural alterations in the coronary circulation, expression of isozymes 11beta-HSD1 and 11beta-HSD2, overview
coexpression of 121beta-HSD1 with hexose-6-phosphate dehydrogenase
low level of expression, low activity; weak expression
isoform 11beta-HSD1 is clearly expressed while isoform 11beta-HSD2 is much less prominent, 11beta-HSD1 protein expression predominates in endothelial cells and varies during periods of growth
expression of isozyme 11beta-HSD1, in situ hybridization, overview
isoform 11beta-HSD1 is highly expressed in freshly isolated omental adipose stromal vascular cells, predominantly in preadipocytes. The enzxyme acts as an 11beta-reduxtase, reactivating glucocorticoids. Glucocorticoid reactivation is higher in intact mesenteric cells than in thigh and axillary depots
11beta-hydroxysteroid dehydrogenase mRNA level together with the markers of late adipocyte differentiation are significantly lower in orbital adipose tissue than in subcutaneous tissue. In primary cultures of orbital preadipocytes, there is predominant 11beta-hydroxysteroid dehydrogenase 1 oxoreductase activity with minimal dehydrogenase activity. Orbital adipocytes are smaller, less differentiated and express low levels of 11beta-hydroxysteroid dehydrogenase, but abundant glucocorticoid receptor compared with subcutaneous omental depots
sucrose can promote increased 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase message in mesenteric fat while concomitantly decreasing 11beta-dehydroxysteroid dehydrogenase message and increasing hexose-6-phosphate dehydrogenase message in liver
in morbidly obese patients, 11beta-hydroxysteroid dehydrogenase 1 mRNA levlels are higher in subcutaneous adipose tissue than in visceral adipose tissue. Subcutaneous adipose tissue 11beta-hydroxysteroid dehydrogenase 1 levels increase parallel according to body mass index category. No correlation between subcutaneous adipose tissue or visceral adipose tissue with fasting glucose, total cholesterol, triglycerides, and high-density lipoprotein
the activity of 11beta-HSD1 is increased in adipose tissue of obese Zucker rats
11beta-HSD1 activity is increased in visceral adipose tissue in prepubertal children with normal weight
methionine restriction induces isoform 11beta-HSD1 activity in all types of adipose tissue examined, correlating with increased tissue corticosterone. Inverse relationship between 11beta-HSD1 activity and adipocyte size is observed. Methionine restriction additionally increases adipose triglyceride lipase and acetyl-coenzyme A carboxylase protein levels
epididymal fat, presence of a functional glucose-6-phosphate-transporter hexose-6-phosphate dehydrogenase 11beta-hydroxysteroid dehydrogenase type 1 system
isoform 11beta-HSD1 is highly expressed in freshly isolated omental adipose stromal vascular cells, predominantly in preadipocytes
differentiation of cells causes a strong increase in 11beta-hydroxysteroid dehydrogenase protein levels, occuring late in the differentiation protocol. Reduction of 11beta-hydroxysteroid dehydrogenase activity in 3T3-L1 fibroblasts, achieved by pharmacological inhibition or adenovirally mediated delivery of short hairpin RNA constructs, specifically blocks the ability of inactive glucocorticoids to drive 3T3-L1 differentiation. Even modest increases in exogenous 11beta-hydroxysteroid dehydrogenase expression in 3T3-L1 fibroblasts, to levels comparable with endogenous 1 11beta-hydroxysteroid dehydrogenase in differentiated 3T3-L1 adipocytes, are sufficient to block adipogenesis
constitutes an important barrier for 11-OH steroids during pregnancy between maternal and fetal organism, presence of two isoforms
two forms present, one NAD-specific the other NADP+-dependent
the 11beta-HSD2 expression and activity is 7-8fold higher compared to 11beta-HSD1 in the chorionic plate of small gestational age placentas
hepatic artery, portal vein, and hepatic vein, local cortisol concentrations, overview
coexpression of 121beta-HSD1 with hexose-6-phosphate dehydrogenase
species-specific reaction profiles of 11beta-hydroxysteroid dehydrogenase, with a five times higher conversion rate in dog than in human and monkey liver microsome
species-specific reaction profiles of 11beta-hydroxysteroid dehydrogenase, with a five times higher conversion rate in dog than in human and monkey liver microsome
sucrose can promote increased 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase message in mesenteric fat while concomitantly decreasing 11beta-dehydroxysteroid dehydrogenase message and increasing hexose-6-phosphate dehydrogenase message in liver
high expression; high level of expression and activity
the activity of 11beta-HSD1 is decreased in the liver of obese Zucker rats
prominent expression in testis, anterior kidney, liver and gills
11beta-HSD1 co-localises with glucagon in the periphery of pancreatic islets, but not with insulin or somatostatin
11beta-HSD1 co-localises with glucagon in the periphery of pancreatic islets, but not with insulin or somatostatin
pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+
prominent expression in testis, anterior kidney, liver and gills. Expression of isoform 11beta-HSD2 in testis and serum levels of 11-ketotestosterone are high in the prespawning phase
cortisol oxidation increases threefold with antral follicle diameter, accompanied by threefold increase in 11beta-hydroxysteroid dehydrogenase activity. Neither intact cells nor homogenates display net 11-ketosteroid reductase activities. Intact granulosa cells from ovarian cysts exhibit significantly lower enzyme activities than cells from large antral follicles
expression of mRNA for 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2 and for glucocorticoid receptor during the estrous cycle. Level of 11beta-hydroxysteroid dehydrogenase type 1 mRNA is higher at the regressed state than at the other stages, whereas level of 11beta-hydroxysteroid dehydrogenase type 2 mRNA is lower at the regressed stage than at the other stages
peripheral lymph nodes and mesenteric lymph nodes
pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+