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Gene ontology
Version 2014-12-22
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Details for glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
2.4.1.175
Gene ontology ID
GO:0047238
Definition
Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP
Synonyms
1. chondroitin synthase activity
2. glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
3. glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity
4. N-acetylgalactosaminyltransferase II activity
5. UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
6. UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity
7. uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity
References
1. EC 2.4.1.175
2. MetaCyc 2.4.1.175-RXN
3. Reactome: R-HSA-1971482 "The addition of GalNAc to the terminal glucuronate residue forms chondroitin"
4. Reactome: R-HSA-1971487 "CHPF,CHSY3 transfer GalNAc to chondroitin"
5. Reactome: R-HSA-3595176 "Defective CHSY1 does not transfer GalNAc to chondroitin"
6. Reactome: R-HSA-9632033 "CHSY1 transfers GalNAc to chondroitin"
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