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Version 2014-12-22
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Details for 1-phosphatidylinositol-4-phosphate 3-kinase activity
2.7.1.154
Gene ontology ID
GO:0035005
Definition
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)
Synonyms
1. ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity
2. C2-domain-containing phosphoinositide 3-kinase activity
3. phosphatidylinositol 3-kinase activity, class I
4. phosphatidylinositol 3-kinase activity, class II
5. phosphatidylinositol 3-kinase, class I, catalyst activity
6. phosphatidylinositol-4-phosphate 3-kinase activity
7. type II phosphoinositide 3-kinase activity
References
1. EC 2.7.1.154
2. RHEA: 18373
3. KEGG REACTION: R05795
4. MetaCyc 2.7.1.154-RXN
5. Reactome: R-HSA-1675928 "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane"
6. Reactome: R-HSA-1676109 "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane"
7. Reactome: R-HSA-1676206 "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane"
8. Reactome: R-HSA-8868072 "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2"
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