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Gene ontology
Version 2014-12-22
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Details for inositol-1,4,5-trisphosphate 3-kinase activity
2.7.1.127
Gene ontology ID
GO:0008440
Definition
Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)
Synonyms
1. 1D-myo-inositol-trisphosphate 3-kinase activity
2. ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity
3. inositol trisphosphate 3-kinase activity
4. inositol-trisphosphate 3-kinase activity
5. ins(1,4,5)P(3) 3-kinase activity
6. Ins(1,4,5)P3 3-kinase activity
7. IP3 3-kinase activity
8. IP3K activity
References
1. EC 2.7.1.127
2. RHEA: 11020
3. KEGG REACTION: R03433
4. MetaCyc 2.7.1.127-RXN
5. Reactome: R-HSA-1855153 "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol"
6. Reactome: R-HSA-1855233 "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus"
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// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
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