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Gene ontology
Version 2014-12-22
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Details for CAAX-protein geranylgeranyltransferase activity
2.5.1.59
Gene ontology ID
GO:0004662
Definition
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families
Synonyms
1. geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2. geranylgeranyltransferase type I activity
3. GGTase-I activity
4. GGTaseI activity
5. protein geranylgeranyltransferase type I
6. type I protein geranyl-geranyltransferase activity
References
1. EC 2.5.1.59
2. PMID 8621375
3. MetaCyc 2.5.1.60-RXN
4. MetaCyc RXN-3701
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
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Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
catalytic activity, acting on a protein is a
protein prenyltransferase activity is a
protein geranylgeranyltransferase activity is a
CAAX-protein geranylgeranyltransferase activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
alpha-1,4-glucan-protein synthase (ADP-forming) activity is a
biotin-protein ligase activity is a
catalytic activity, acting on a glycoprotein is a
deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity is a
dihydrolipoyllysine-residue acetyltransferase activity is a
dihydrolipoyllysine-residue succinyltransferase activity is a
GPI-anchor transamidase activity is a
lipoate-protein ligase activity is a
peptidyl-aspartic acid 3-dioxygenase activity is a
peptidyl-lysine N6-palmitoyltransferase activity is a
peptidylamidoglycolate lyase activity is a
phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity is a
polypeptide N-acetylgalactosaminyltransferase activity is a
procollagen galactosyltransferase activity is a
procollagen glucosyltransferase activity is a
protein disulfide isomerase activity is a
protein methylesterase activity is a
protein methylthiotransferase activity is a
protein N-acetylglucosaminyltransferase activity is a
protein O-GlcNAc transferase activity is a
protein prenyltransferase activity is a
protein farnesyltransferase activity is a
protein geranylgeranyltransferase activity is a
CAAX-protein geranylgeranyltransferase activity is a
Rab geranylgeranyltransferase activity is a
protein xylosyltransferase activity is a
protein-cysteine S-acyltransferase activity is a
protein-fructosamine 3-kinase activity is a
protein-glucosylgalactosylhydroxylysine glucosidase activity is a
protein-glutamic acid ligase activity is a
protein-glycine ligase activity is a
protein-ribulosamine 3-kinase activity is a
protein-tyrosine sulfotransferase activity is a
Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity is a
transferase activity, transferring amino-acyl groups is a
tubulin-tyrosine ligase activity is a
ubiquitin-like protein transferase activity is a
ubiquitinyl hydrolase activity is a
[acyl-carrier-protein] phosphodiesterase activity is a
[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase is a
[protein-PII] uridylyltransferase activity is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a