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Gene ontology
Version 2014-12-22
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Details for estradiol 17-beta-dehydrogenase activity
1.1.1.62
Gene ontology ID
GO:0004303
Definition
Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+
Synonyms
1. 17-beta-estradiol dehydrogenase activity
2. 17-beta-HSD activity
3. 17-beta-hydroxysteroid dehydrogenase activity
4. 17beta,20alpha-hydroxysteroid dehydrogenase activity
5. 17beta-estradiol dehydrogenase activity
6. 17beta-HSD
7. 17beta-hydroxysteroid dehydrogenase activity
8. 20alpha-hydroxysteroid dehydrogenase
9. estradiol 17beta-dehydrogenase activity
10. estradiol dehydrogenase activity
11. estradiol-17beta:NAD(P)+ 17-oxidoreductase activity
12. estrogen 17-oxidoreductase activity
References
1. EC 1.1.1.62
2. MetaCyc ESTRADIOL-17-BETA-DEHYDROGENASE-RXN
3. Reactome: R-HSA-5693390 "HSD17B11 dehydrogenates EST17b to E1"
4. Reactome: R-HSA-5696822 "AKR1B15 reduces EST17b to E1"
5. Reactome: R-HSA-6810594 "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)"
6. Reactome: R-HSA-804969 "HSD17B1 hydrogenates E1 to EST17b"
7. Reactome: R-HSA-8862137 "HSD17B2 oxidises estradiol (E2) to estrone (E1)"
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