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Gene ontology
Version 2014-12-22
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Details for arachidonate 12(S)-lipoxygenase activity
1.13.11.31
Gene ontology ID
GO:0004052
Definition
Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
Synonyms
1. 12-lipoxygenase activity
2. 12Delta-lipoxygenase activity
3. 12S-lipoxygenase activity
4. arachidonate:oxygen 12-oxidoreductase activity
5. C-12 lipoxygenase activity
6. delta12-lipoxygenase activity
7. leukotriene A4 synthase
8. LTA4 synthase activity
References
1. EC 1.13.11.31
2. RHEA: 10428
3. KEGG REACTION: R01596
4. MetaCyc ARACHIDONATE-12-LIPOXYGENASE-RXN
5. Reactome: R-HSA-2161948 "Arachidonic acid is converted to 12-oxoETE by ALOX12"
6. Reactome: R-HSA-2161950 "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B"
7. Reactome: R-HSA-2161964 "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15"
8. Reactome: R-HSA-9024983 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA"
9. Reactome: R-HSA-9025957 "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6"
10. Reactome: R-HSA-9026006 "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3"
11. Reactome: R-HSA-9026007 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
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Condensed Tree View
Gene ontology
biological_process is a
metabolic process is a
oxidation-reduction process is a
oxidoreductase activity part of
dioxygenase activity is a
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen is a
arachidonate 12(S)-lipoxygenase activity is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
adaptive thermogenesis is a
ATP metabolic process is a
biosynthetic process is a
catabolic process is a
collagen metabolic process is a
demethylation is a
glycosylation is a
hydrogen metabolic process is a
methylation is a
multi-organism metabolic process is a
NAD metabolic process is a
NADH metabolic process is a
NADP metabolic process is a
nitrogen compound metabolic process is a
organic substance metabolic process is a
oxidation-reduction process is a
iodide oxidation is a
oxidative deethylation is a
oxidoreductase activity part of
1,1,1-trichloroethane reductive dehalogenase activity is a
1,1,2-trichloroethene reductive dehalogenase activity is a
1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity is a
1,1-dichloroethane reductive dehalogenase activity is a
1,2-dichloroethene reductive dehalogenase activity is a
2,4-dichloroaniline reductive dehalogenase activity is a
2,4-dichlorophenoxyacetate dehalogenase activity is a
2,5-dichlorohydroquinone reductive dehalogenase activity is a
2-chloro-N-isopropylacetanilide reductive dehalogenase activity is a
2-octaprenylphenol hydroxylase activity is a
2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity is a
3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity is a
3,3',5-tribromobisphenol A reductive dehalogenase activity is a
3,3'-dibromobisphenol A reductive dehalogenase activity is a
3,8-divinyl protochlorophyllide a 8-vinyl reductase activity is a
3-monobromobisphenol A reductive dehalogenase activity is a
alpha-ketoacid dehydrogenase activity is a
arsenate reductase activity is a
chlorate reductase activity is a
chromate reductase activity is a
crotonyl-CoA reductase activity is a
delta1-piperideine-6-carboxylate dehydrogenase activity is a
dihydronicotinamide riboside quinone reductase activity is a
dihydropterin oxidase activity is a
dimethylarsinate reductase activity is a
dioxygenase activity is a
1,2-dihydroxynaphthalene dioxygenase activity is a
2-oxoglutarate-dependent dioxygenase activity is a
3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity is a
3-butenylglucosinolate 2-hydroxylase activity is a
alpha-ketoglutarate-dependent xanthine dioxygenase activity is a
DDT 2,3-dioxygenase activity is a
DOPA dioxygenase activity is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor is a
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen is a
1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity is a
1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity is a
1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity is a
1-hydroxy-2-naphthoate 1,2-dioxygenase activity is a
2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity is a
2,2',3-trihydroxybiphenyl dioxygenase activity is a
2,3-dihydroxy DDT 1,2-dioxygenase activity is a
2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity is a
2,3-dihydroxy-p-cumate dioxygenase activity is a
2,3-dihydroxybenzoate 2,3-dioxygenase activity is a
2,3-dihydroxybenzoate 3,4-dioxygenase activity is a
2,3-dihydroxybiphenyl 1,2-dioxygenase activity is a
2,3-dihydroxydiphenyl ether dioxygenase activity is a
2,3-dihydroxyindole 2,3-dioxygenase activity is a
2,4'-dihydroxyacetophenone dioxygenase activity is a
2,5-dihydroxypyridine 5,6-dioxygenase activity is a
2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity is a
2-aminophenol 1,6-dioxygenase activity is a
2-mercaptobenzothiazole dioxygenase activity is a
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity is a
3,4-dihydroxyphenanthrene dioxygenase activity is a
3,4-dihydroxyphenylacetate 2,3-dioxygenase activity is a
3,5-dichlorocatechol 1,2-dioxygenase activity is a
3-carboxyethylcatechol 2,3-dioxygenase activity is a
3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity is a
3-hydroxy-2-naphthoate 2,3-dioxygenase activity is a
3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity is a
3-hydroxyanthranilate 3,4-dioxygenase activity is a
4,5-dihydroxybenzo(a)pyrene dioxygenase activity is a
4,5-dihydroxypyrene dioxygenase activity is a
4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity is a
4-hydroxycatechol 1,2-dioxygenase activity is a
4-hydroxymandelate synthase activity is a
4-hydroxyphenylpyruvate dioxygenase activity is a
5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity is a
5,6-dimethylbenzimidazole synthase activity is a
5-aminosalicylate dioxygenase activity is a
7,8-dihydroxy benzo(a)pyrene dioxygenase activity is a
7,8-dihydroxykynurenate 8,8a-dioxygenase activity is a
9,10-dihydroxybenzo(a)pyrene dioxygenase activity is a
9-cis-10'-apo-beta-carotenal cleavage oxygenase activity is a
9-cis-beta-carotene 9',10'-cleavage oxygenase activity is a
acetylacetone-cleaving enzyme activity is a
acireductone dioxygenase (Ni2+-requiring) activity is a
acireductone dioxygenase [iron(II)-requiring] activity is a
all-trans-8'-apo-beta-carotenal 15,15'-oxygenase is a
all-trans-beta-apo-10'-carotenal cleavage oxygenase activity is a
arachidonate 12(R)-lipoxygenase activity is a
arachidonate 12(S)-lipoxygenase activity is a
arachidonate 15-lipoxygenase activity is a
arachidonate 5-lipoxygenase activity is a
arachidonate 8(R)-lipoxygenase activity is a
arachidonate 8(S)-lipoxygenase activity is a
benzo(a)pyrene 11,12-dioxygenase activity is a
benzo(a)pyrene 4,5-dioxygenase activity is a
benzo(a)pyrene 7,8-dioxygenase activity is a
benzo(a)pyrene 9,10-dioxygenase activity is a
beta,beta-carotene-9',10'-cleaving oxygenase activity is a
beta-carotene 15,15'-monooxygenase activity is a
beta-carotene oxygenase activity is a
biphenyl-2,3-diol 1,2-dioxygenase activity is a
caffeate 3,4-dioxygenase activity is a
carbazole 1,9a-dioxygenase activity is a
carotenoid dioxygenase activity is a
catechol dioxygenase activity is a
chloridazon-catechol dioxygenase activity is a
chlorite O2-lyase activity is a
chlorocatechol 1,2-dioxygenase activity is a
cysteamine dioxygenase activity is a
cysteine dioxygenase activity is a
dihydroxydibenzothiophene dioxygenase activity is a
dihydroxyfluorene dioxygenase activity is a
diphenyl ether 1,2-dioxygenase activity is a
fatty acid alpha-oxygenase activity is a
gallate dioxygenase activity is a
gentisate 1,2-dioxygenase activity is a
homogentisate 1,2-dioxygenase activity is a
hydroquinone 1,2-dioxygenase activity is a
hydroxyquinol 1,2-dioxygenase activity is a
indole 2,3-dioxygenase activity is a
indoleamine 2,3-dioxygenase activity is a
lignostilbene alpha beta-dioxygenase activity is a
linoleate 11-lipoxygenase activity is a
linoleate 13S-lipoxygenase activity is a
linoleate 8R-lipoxygenase is a
linoleate 8R-lipoxygenase activity is a
linoleate 9R-lipoxygenase activity is a
linoleate 9S-lipoxygenase activity is a
linolenate 9R-lipoxygenase activity is a
lutein oxygenase activity is a
p-cumate 2,3-dioxygenase activity is a
peptide-tryptophan 2,3-dioxygenase activity is a
phenanthrene dioxygenase activity is a
phenanthrene-4-carboxylate dioxygenase activity is a
protocatechuate 3,4-dioxygenase activity is a
protocatechuate 3,4-dioxygenase type II activity is a
protocatechuate 4,5-dioxygenase activity is a
pyrene dioxygenase activity is a
pyridine-3,4-diol dioxygenase activity is a
pyrogallol 1,2-oxygenase activity is a
quercetin 2,3-dioxygenase activity is a
stizolobate synthase activity is a
stizolobinate synthase activity is a
styrene dioxygenase activity is a
sulfur dioxygenase activity is a
sulfur oxygenase/reductase activity is a
tetrachlorobenzene dioxygenase activity is a
tryptophan 2,3-dioxygenase activity is a
violaxanthin oxygenase activity is a
epoxyqueuosine reductase activity is a
fatty acid alpha-hydroxylase activity is a
geranylgeranyl reductase activity is a
glycyl-radical enzyme activating activity is a
heme-copper terminal oxidase activity is a
hydroxymethylbutenyl pyrophosphate reductase activity is a
malolactic enzyme activity is a
monooxygenase activity is a
NADPH-adrenodoxin reductase activity is a
NADPH:sulfur oxidoreductase activity is a
ortho-trichlorophenol reductive dehalogenase activity is a
oxidoreductase activity, acting on a heme group of donors is a
oxidoreductase activity, acting on a sulfur group of donors is a
oxidoreductase activity, acting on CH or CH2 groups is a
oxidoreductase activity, acting on CH-OH group of donors is a
oxidoreductase activity, acting on diphenols and related substances as donors is a
oxidoreductase activity, acting on halogen in donors is a
oxidoreductase activity, acting on hydrogen as donor is a
oxidoreductase activity, acting on iron-sulfur proteins as donors is a
oxidoreductase activity, acting on NAD(P)H is a
oxidoreductase activity, acting on other nitrogenous compounds as donors is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is a
oxidoreductase activity, acting on peroxide as acceptor is a
oxidoreductase activity, acting on phosphorus or arsenic in donors is a
oxidoreductase activity, acting on reduced flavodoxin as donor is a
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is a
oxidoreductase activity, acting on superoxide radicals as acceptor is a
oxidoreductase activity, acting on the aldehyde or oxo group of donors is a
oxidoreductase activity, acting on the CH-CH group of donors is a
oxidoreductase activity, acting on the CH-NH group of donors is a
oxidoreductase activity, acting on the CH-NH2 group of donors is a
oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond is a
oxidoreductase activity, oxidizing metal ions is a
oxygen evolving activity is a
perchlorate reductase activity is a
phthalate dioxygenase reductase activity is a
pyrogallol hydroxytransferase activity is a
reduced coenzyme F420 dehydrogenase activity is a
reduced coenzyme F420 oxidase activity is a
reduced coenzyme F420:quinone oxidoreductase activity is a
selenate reductase activity is a
sphingosine hydroxylase activity is a
steroid dehydrogenase activity is a
sulfur oxygenase reductase activity is a
sulfur reductase activity is a
tetrachloroethene reductive dehalogenase activity is a
tetrahydrothiophene 1-oxide reductase activity is a
thyroxine 5'-deiodinase activity is a
thyroxine 5-deiodinase activity is a
trimethylarsine oxidase activity is a
tyramine-beta hydroxylase activity is a
uracil oxygenase activity is a
vinyl chloride reductive dehalogenase activity is a
violaxanthin de-epoxidase activity is a
thioredoxin reduction is a
pigment metabolic process is a
primary metabolic process is a
respiratory burst is a
secondary metabolic process is a
small molecule metabolic process is a
tartrate metabolic process is a
tyrocidine metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a