Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
1. EC 2.4.2.302. MetaCyc NAD+-ADP-RIBOSYLTRANSFERASE-RXN3. Reactome: R-HSA-2187325 "PARP1 ADP-ribosylates SMAD3 and SMAD4"
4. Reactome: R-HSA-3640858 "Tankyrase ADP-ribosylates AXIN"
5. Reactome: R-HSA-5651723 "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate"
6. Reactome: R-HSA-5687653 "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate"
7. Reactome: R-HSA-5688276 "SIRT4 transfers ADPRib to GLUD"
8. Reactome: R-HSA-8938073 "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)"
9. Reactome: R-HSA-8948800 "TNKS and TNKS2 PARylate PTEN"