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Gene ontology
Version 2014-12-22
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Details for NAD+ ADP-ribosyltransferase activity
2.4.2.30
Gene ontology ID
GO:0003950
Definition
Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Synonyms
1. ADP-ribosyltransferase (polymerizing) activity
2. NAD ADP-ribosyltransferase activity
3. NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity
4. poly(adenosine diphosphate ribose) polymerase activity
5. poly(ADP-ribose) synthase activity
6. poly(ADP-ribose) synthetase activity
7. poly(ADP-ribose)polymerase activity
References
1. EC 2.4.2.30
2. MetaCyc NAD+-ADP-RIBOSYLTRANSFERASE-RXN
3. Reactome: R-HSA-2187325 "PARP1 ADP-ribosylates SMAD3 and SMAD4"
4. Reactome: R-HSA-3640858 "Tankyrase ADP-ribosylates AXIN"
5. Reactome: R-HSA-5651723 "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate"
6. Reactome: R-HSA-5687653 "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate"
7. Reactome: R-HSA-5688276 "SIRT4 transfers ADPRib to GLUD"
8. Reactome: R-HSA-8938073 "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)"
9. Reactome: R-HSA-8948800 "TNKS and TNKS2 PARylate PTEN"
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