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Gene ontology
Version 2014-12-22
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Details for DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
5.6.2.2
Gene ontology ID
GO:0003918
Definition
Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2
Synonyms
1. deoxyribonucleate topoisomerase
2. deoxyribonucleic topoisomerase activity
3. DNA topoisomerase (ATP-hydrolysing)
4. DNA topoisomerase II
5. DNA topoisomerase II activity
6. DNA topoisomerase IV activity
7. DNA topoisomerase type II activity
8. topoisomerase
9. topoisomerase II
10. type II DNA topoisomerase activity
References
1. PMID 8811192
2. EC 5.6.2.2
3. MetaCyc 5.99.1.3-RXN
4. Wikipedia: Type II topoisomerase
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