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Literature summary for 6.5.1.1 extracted from

  • Sinha, K.M.; Hines, J.C.; Ray, D.S.
    Cell cycle-dependent localization and properties of a second mitochondrial DNA ligase in Crithidia fasciculata (2006), Eukaryot. Cell, 5, 54-61.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.5.1.1

Localization

Localization Comment Organism GeneOntology No. Textmining
kinetoplast LIG k alpha localizes to the kinetoplast primarily in cells that have completed mitosis and contain either a dividing kinetoplast or two newly divided kinetoplasts. The ligase is present on both faces of the kDNA disk and at a high level in the kinetoflagellar zone of the mitochondrial matrix Crithidia fasciculata 20023
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mitochondrion
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 Crithidia fasciculata 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Crithidia fasciculata possible role of the ligase in regulating minicircle replication AMP + diphosphate + (deoxyribonucleotide)m+n
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 ?

Organism

Organism UniProt Comment Textmining
Crithidia fasciculata
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-
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Source Tissue

Source Tissue Comment Organism Textmining
cell culture LIG k alpha localizes to the kinetoplast primarily in cells that have completed mitosis and contain either a dividing kinetoplast or two newly divided kinetoplasts. The ligase is present on both faces of the kDNA disk and at a high level in the kinetoflagellar zone of the mitochondrial matrix. LIG k alpha transcript levels are maximal during the phase when cells contain two nuclei Crithidia fasciculata
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m possible role of the ligase in regulating minicircle replication Crithidia fasciculata AMP + diphosphate + (deoxyribonucleotide)m+n
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 ?

Synonyms

Synonyms Comment Organism
LIG k alpha
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 Crithidia fasciculata