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Literature summary for 6.5.1.1 extracted from

  • Wang, H.; Zeng, Z.C.; Perrault, A.R.; Cheng, X.; Qin, W.; Iliakis, G.
    Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells (2001), Nucleic Acids Res., 29, 1653-1660.
    View publication on PubMedView publication on EuropePMC
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Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens DNA ligase IV is involved in DNA-protein kinase-dependent form of non-homologous end joining AMP + diphosphate + (deoxyribonucleotide)m+n
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m DNA ligase IV is involved in DNA-protein kinase-dependent form of non-homologous end joining Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Synonyms

Synonyms Comment Organism
DNA ligase IV
-
 Homo sapiens