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Literature summary for 6.5.1.1 extracted from
- Vaccinia virus DNA ligase: specificity, fidelity, and inhibition (1995), Biochemistry, 34, 16138-16147.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3'-dATP | - |
Vaccinia virus |  |
| actinomycin | - |
Vaccinia virus | |
| ATPalphaS | - |
Vaccinia virus | |
| Distamycin | - |
Vaccinia virus | |
| Ethidium bromide | - |
Vaccinia virus | |
| additional information | inhibited strongly by mismatches at the 3'-OH acceptor terminus | Vaccinia virus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Vaccinia virus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | unable to seal strands across a 1 nucleotide or 2 nucleotide gap. Ligase action at a 1 nucleotide gap results in accumulation of high levels of the normally undetectable DNA-adenylate reaction intermediate, no DNA-adenylate is formed at a 2 nucleotide gap | Vaccinia virus | AMP + diphosphate + (deoxyribonucleotide)n+m | - |
? | |
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